WormBase Tree Display for Gene: WBGene00000821

WBGene00000821 SMap: S_parent: Sequence: Y47H9C
  Identity: Version: 2
    Name: CGC_name: csp-3 Person_evidence: WBPerson576
      Sequence_name: Y47H9C.6
      Molecular_name: Y47H9C.6a
        Y47H9C.6a.1
        CE27635
        Y47H9C.6b
      Other_name: CELE_Y47H9C.6 Accession_evidence: NDB BX284601
      Public_name: csp-3
    DB_info: Database: AceView gene 1M480
        WormQTL gene WBGene00000821
        WormFlux gene WBGene00000821
        NDB locus_tag CELE_Y47H9C.6
        Panther gene CAEEL|WormBase=WBGene00000821|UniProtKB=G5ECW5
          family PTHR10454
        NCBI gene 190006
        RefSeq protein NM_060610.4
            NR_138525.1
        SwissProt UniProtAcc G5ECW5
        UniProt_GCRP UniProtAcc G5ECW5
        RNAcentral URSid URS0000A040E4
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 19 Apr 2016 17:09:35 WBPerson1983 Event: Acquires_merge: WBGene00012957
      Acquires_merge: WBGene00012957
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: csp
    Allele (49)
    Strain: WBStrain00032148
      WBStrain00027534
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog: CBOVI.g8214 Caenorhabditis bovis From_analysis: WormBase-Compara
      Cnig_chr_IV.g16094 Caenorhabditis nigoni From_analysis: WormBase-Compara
      chrI_pilon.g2354 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00286714 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0026404 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            PhylomeDB
      ZFIN:ZDB-GENE-000713-1 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
      ZFIN:ZDB-GENE-030825-3 Danio rerio From_analysis: EnsEMBL-Compara
            PhylomeDB
      ZFIN:ZDB-GENE-070608-2 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
      ZFIN:ZDB-GENE-060526-186 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
      ZFIN:ZDB-GENE-081022-114 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
    Paralog: WBGene00000417 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000819 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000820 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: csp-3 encodes a protein that is homologous to the C-terminal domain (small subunit) of caspase-like cysteine proteases, including CED-3; unlike other caspases, CSP-3 does not contain a middle or N-terminal domain; during development, csp-3 functions to negatively regulate programmed cell death; csp-3 activity is also required for embryonic development and coordinated locomotion; CSP-3 physically associates with CED-3 both in vitro and in vivo and can inhibit autoactivation of CED-3; a CSP-3::GFP reporter protein is expressed ubiquitously in embryos where it localizes to the cytoplasm. Paper_evidence: WBPaper00003342
            WBPaper00004402
            WBPaper00032164
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Jul 2009 00:00:00
      Automated_description: Enables caspase binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zymogen binding activity. Involved in positive regulation of behavior; positive regulation of embryonic development; and regulation of apoptotic process. Located in cytoplasm. Expressed in several structures, including germ line. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y47H9C.6a
    Corresponding_CDS_history: Y47H9C.6:wp50
    Corresponding_transcript: Y47H9C.6b
      Y47H9C.6a.1
    Other_sequence: AF088290
    Associated_feature: WBsf985407
      WBsf985408
      WBsf985409
      WBsf1010803
  Experimental_info: RNAi_result: WBRNAi00004667 Inferred_automatically: RNAi_primary
      WBRNAi00056851 Inferred_automatically: RNAi_primary
      WBRNAi00058345 Inferred_automatically: RNAi_primary
      WBRNAi00056846 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8958
      Expr10792
      Expr1011429
      Expr1013265
      Expr1160298
      Expr1160302
      Expr2010559
      Expr2028799
    Drives_construct: WBCnstr00004605
      WBCnstr00013637
    Construct_product: WBCnstr00004605
      WBCnstr00013637
    Antibody: WBAntibody00001877
    Microarray_results (18)
    Expression_cluster (81)
    Interaction: WBInteraction000133984
      WBInteraction000133985
      WBInteraction000288549
      WBInteraction000303099
      WBInteraction000379964
      WBInteraction000420523
      WBInteraction000540820
  Map_info: Map: I Position: 12.9054 Error: 0.003378
    Positive: Positive_clone: Y47H9C Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5594
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene