WormBase Tree Display for Gene: WBGene00000787
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| WBGene00000787 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C41D11 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cps-6 | Person_evidence | WBPerson1606 | |||||
| Sequence_name | C41D11.8 | ||||||||
| Molecular_name | C41D11.8 | ||||||||
| C41D11.8.1 | |||||||||
| CE29488 | |||||||||
| Other_name | CELE_C41D11.8 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | cps-6 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cps | ||||||||
| Allele (33) | |||||||||
| Legacy_information | Recessive mutation sm116 weakly suppresses neuronal cell deaths and enhances suppression by ced-8(n1891). Encodes mitochondrial endonuclease G. | ||||||||
| Strain | WBStrain00036451 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Contained_in_operon | CEOP1180 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | cps-6 encodes an ortholog of human mitochondrial endonuclease G (EndoG) that promotes apoptosis, and is required to degrade nicked (TUNEL-positive) DNA in apoptotic cells; transgenic CPS-6 is localized to mitochondria, but transgenic CPS-6 lacking a mitochondrial localization sequence is found in nuclei, and nuclei may be the in vivo target of CPS-6 after its activation by CED-3; CPS-6 has magnesium-dependent nuclease activity in vitro and can degrade both single- and double-stranded DNA, as well as single-stranded RNA; CPS-6 also preferentially binds G-tract DNA in vitro; cps-6(sm116) and cps-6(RNAi) animals have delayed CED-3-induced apoptosis, and cps-6(sm116) suppresses a constitutively active ced-3 transgene; cps-6(sm116) can be transgenically rescued by mouse EndoG; CPS-6 binds WAH-1 (an apoptosis-inducing factor ortholog) in vitro, WAH-1 binding enhances CPS-6's endonuclease activity, and constitutive transgenic coexpression of cps-6 with wah-1 induces cell death not seen with constitutive expression of either cps-6 or wah-1 alone; CPS-6 binds CRN-1 (a flap endonuclease ortholog) in vitro, and may form a large complex in vivo with CRN-1, CRN-4, CRN-5, CYP-13, and WAH-1; CRN-1 enhances CPS-6's endonuclease activity in vitro, CPS-6 enhances CRN-1's gap-dependent endonuclease and 5'-3' exonuclease activities, and cps-6 is required for excess cell deaths induced by a crn-1 transgene. | Paper_evidence | WBPaper00004743 | |||||
| WBPaper00005558 | |||||||||
| WBPaper00005857 | |||||||||
| WBPaper00005978 | |||||||||
| WBPaper00028402 | |||||||||
| WBPaper00040583 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Feb 2012 00:00:00 | ||||||||
| Automated_description | Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrion. Is an ortholog of human ENDOG (endonuclease G). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C41D11.8 | |||||||
| Corresponding_transcript | C41D11.8.1 | ||||||||
| Other_sequence (38) | |||||||||
| Associated_feature | WBsf219272 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00005011 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00087543 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097790 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097791 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042291 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097793 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00097792 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1493 | ||||||||
| Expr1015388 | |||||||||
| Expr1030488 | |||||||||
| Expr1146282 | |||||||||
| Expr2010509 | |||||||||
| Expr2028749 | |||||||||
| Construct_product | WBCnstr00010306 | ||||||||
| Antibody | WBAntibody00002303 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (109) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000103 | |||||||||
| WBbiopr:00000106 | |||||||||
| Map_info | Map | I | Position | -1.30373 | Error | 0.003427 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C41D11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4020 | |||||||
| 4021 | |||||||||
| Reference (25) | |||||||||
| Remark | Data extracted from Parrish et al (2001) | ||||||||
| Sequence connection updated to C41D11.8 based on email from Jean & Danielle and John Spieth (citing GenBank AF390558) | |||||||||
| Method | Gene |
