| WBGene00000787 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | C41D11 |
| Identity | Version | 1 |
| | Name | CGC_name | cps-6 | Person_evidence | WBPerson1606 |
| | | Sequence_name | C41D11.8 |
| | | Molecular_name | C41D11.8 |
| | | | C41D11.8.1 |
| | | | CE29488 |
| | | Other_name | CELE_C41D11.8 | Accession_evidence | NDB | BX284601 |
| | | Public_name | cps-6 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cps |
| | Allele (33) |
| | Legacy_information | Recessive mutation sm116 weakly suppresses neuronal cell deaths and enhances suppression by ced-8(n1891). Encodes mitochondrial endonuclease G. |
| | Strain | WBStrain00036451 |
| | RNASeq_FPKM (74) |
| | GO_annotation (34) |
| | Contained_in_operon | CEOP1180 |
| | Ortholog (36) |
| | Structured_description | Concise_description | cps-6 encodes an ortholog of human mitochondrial endonuclease G (EndoG) that promotes apoptosis, and is required to degrade nicked (TUNEL-positive) DNA in apoptotic cells; transgenic CPS-6 is localized to mitochondria, but transgenic CPS-6 lacking a mitochondrial localization sequence is found in nuclei, and nuclei may be the in vivo target of CPS-6 after its activation by CED-3; CPS-6 has magnesium-dependent nuclease activity in vitro and can degrade both single- and double-stranded DNA, as well as single-stranded RNA; CPS-6 also preferentially binds G-tract DNA in vitro; cps-6(sm116) and cps-6(RNAi) animals have delayed CED-3-induced apoptosis, and cps-6(sm116) suppresses a constitutively active ced-3 transgene; cps-6(sm116) can be transgenically rescued by mouse EndoG; CPS-6 binds WAH-1 (an apoptosis-inducing factor ortholog) in vitro, WAH-1 binding enhances CPS-6's endonuclease activity, and constitutive transgenic coexpression of cps-6 with wah-1 induces cell death not seen with constitutive expression of either cps-6 or wah-1 alone; CPS-6 binds CRN-1 (a flap endonuclease ortholog) in vitro, and may form a large complex in vivo with CRN-1, CRN-4, CRN-5, CYP-13, and WAH-1; CRN-1 enhances CPS-6's endonuclease activity in vitro, CPS-6 enhances CRN-1's gap-dependent endonuclease and 5'-3' exonuclease activities, and cps-6 is required for excess cell deaths induced by a crn-1 transgene. | Paper_evidence | WBPaper00004743 |
| | | | | | WBPaper00005558 |
| | | | | | WBPaper00005857 |
| | | | | | WBPaper00005978 |
| | | | | | WBPaper00028402 |
| | | | | | WBPaper00040583 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Feb 2012 00:00:00 |
| | | Automated_description | Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrion. Is an ortholog of human ENDOG (endonuclease G). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C41D11.8 |
| | Corresponding_transcript | C41D11.8.1 |
| | Other_sequence (38) |
| | Associated_feature | WBsf219272 |
| Experimental_info | RNAi_result | WBRNAi00005011 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00087543 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00097790 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00097791 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00042291 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00097793 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00097792 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1493 |
| | | Expr1015388 |
| | | Expr1030488 |
| | | Expr1146282 |
| | | Expr2010509 |
| | | Expr2028749 |
| | Construct_product | WBCnstr00010306 |
| | Antibody | WBAntibody00002303 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:hypodermis_larva_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:intestine_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040209:B.thuringiensis_upregulated_N2 |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045729:gld-2(RNAi)_upregulated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049177:rpn-10(ok1865)_upregulated |
| | | WBPaper00049217:TCER-1_downregulated |
| | | WBPaper00049290:rsks-1(sv31)_downregulated |
| | | WBPaper00049368:daf-2(e1370)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_upregulated |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053810:clk-1(qm30)_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:isp-1(qm150)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00053810:sod-2(ok1030)_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055941:nuo-6(qm200)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:ifo-1(kc2)_upregulated |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_protein |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:set-2(bn129)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27) |
| | | WBPaper00060084:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061390:daf-22(ok693)_ascarosides_downregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:C32F10.4-D1086.2 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064005:starvation_upregulated_N2_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064637:cox-5B(RNAi)_upregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | cgc4386_cluster_1_4 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_7 |
| | | WBPaper00032948:StarveUp4 |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040963:Q100_up |
| | | WBPaper00040963:Q200_up |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00049538:atfs-1(et18)_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (109) |
| | WBProcess | WBbiopr:00000014 |
| | | WBbiopr:00000103 |
| | | WBbiopr:00000106 |
| Map_info | Map | I | Position | -1.30373 | Error | 0.003427 |
| | Well_ordered |
| | Positive | Positive_clone | C41D11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4020 |
| | | | 4021 |
| Reference (25) |
| Remark | Data extracted from Parrish et al (2001) |
| | Sequence connection updated to C41D11.8 based on email from Jean & Danielle and John Spieth (citing GenBank AF390558) |
| Method | Gene |
