WormBase Tree Display for Gene: WBGene00000561

WBGene00000561 Evidence: Paper_evidence: WBPaper00004409
  SMap: S_parent: Sequence: C34E10
  Identity: Version: 1
    Name: CGC_name: cnd-1 Person_evidence: WBPerson105
            WBPerson293
      Sequence_name: C34E10.7
      Molecular_name: C34E10.7
        C34E10.7.1
        CE01187
      Other_name: hlh-5 Person_evidence: WBPerson346
        C34E10.d Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        C34E10 Paper_evidence: WBPaper00027608
        CeND Paper_evidence: WBPaper00027608
        CELE_C34E10.7 Accession_evidence: NDB BX284603
      Public_name: cnd-1
    DB_info: Database: AceView gene 3G328
        WormQTL gene WBGene00000561
        WormFlux gene WBGene00000561
        OMIM disease 125853
            606394
          gene 601724
            601725
        NDB locus_tag CELE_C34E10.7
        Panther gene CAEEL|WormBase=WBGene00000561|UniProtKB=P46581
          family PTHR19290
        NCBI gene 183212
        RefSeq protein NM_001392092.1
        SwissProt UniProtAcc P46581
        UniProt_GCRP UniProtAcc P46581
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cnd
    Allele (58)
    Strain: WBStrain00029627
      WBStrain00029628
      WBStrain00036693
      WBStrain00036763
      WBStrain00005364
      WBStrain00029967
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (57)
    Paralog: WBGene00001957 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00003595 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00001953 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00001960 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001961 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003018 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009540 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013665 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: cnd-1 encodes a basic helix-loop-helix protein that is most closely related to the vertebrate NeuroD transcription factors; during development, CND-1 is predicted to function as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding; CND-1::GFP expression begins in early embryogenesis (<20 cells) in four AB descendants and then continues in mitotically active AB-derived neuronal precursors, unidentified nuclei during gastrulation and enclosure, and postmitotic neurons in the head and ventral cord; at hatching CND-1::GFP expression is visible in ventral cord neurons, but this expression disappears completely by the end of the first larval stage; CND-1::GFP does not appear to be expressed in any non-neuronal ectodermal cells, as its expression does not overlap with that of LIN-26. Paper_evidence: WBPaper00004409
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 11 May 2006 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in axonal fasciculation and negative regulation of gliogenesis. Located in nucleus. Expressed in several structures, including ABalpapaa; ABalppapa; motor neurons; neuroblasts; and somatic nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72; glucose metabolism disease (multiple); and obesity. Is an ortholog of several human genes including NEUROD1 (neuronal differentiation 1); NEUROD2 (neuronal differentiation 2); and NEUROD4 (neuronal differentiation 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7762)
      DOID:4195 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7762)
      DOID:10603 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7762)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7762)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7762)
      DOID:0111104 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7762)
      DOID:0112208 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7763)
    Disease_relevance: In humans, mutations in Neurogenic Differentiation 1 (NeuroD1) have been implicated in Diabetes Mellitus, Type II and Maturity-onset diabetes of the young, type VI; in elegans, cnd-1, seems to have combined the function of several vertebrate neurogenic bHLH proteins, and is required for the proper fate specification and terminal differentiation of motor neurons. Homo sapiens Paper_evidence: WBPaper00004409
          Accession_evidence: OMIM 606394
              125853
              601724
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Sep 2013 00:00:00
  Molecular_info: Corresponding_CDS: C34E10.7
    Corresponding_transcript: C34E10.7.1
    Other_sequence: Dviv_isotig35392
      Dviv_isotig31167
      JI178639.1
      Tcol_isotig15910
    Associated_feature: WBsf651039
      WBsf666900
      WBsf978355
      WBsf992340
      WBsf992341
      WBsf226653
    Transcription_factor: WBTranscriptionFactor000076
      WBTranscriptionFactor000060
  Experimental_info: RNAi_result: WBRNAi00107382 Inferred_automatically: RNAi_primary
      WBRNAi00041895 Inferred_automatically: RNAi_primary
      WBRNAi00029528 Inferred_automatically: RNAi_primary
      WBRNAi00005521 Inferred_automatically: RNAi_primary
      WBRNAi00066068 Inferred_automatically: RNAi_primary
      WBRNAi00011606 Inferred_automatically: RNAi_primary
    Expr_pattern (18)
    Drives_construct: WBCnstr00004609
      WBCnstr00004610
      WBCnstr00004611
      WBCnstr00013822
      WBCnstr00015211
      WBCnstr00015212
      WBCnstr00015213
      WBCnstr00037451
      WBCnstr00042892
      WBCnstr00042894
    Construct_product: WBCnstr00013822
      WBCnstr00015371
      WBCnstr00015372
      WBCnstr00016754
      WBCnstr00016967
      WBCnstr00021504
      WBCnstr00037451
    Regulate_expr_cluster: WBPaper00059932:cnd-1(ju29)_downregulated
      WBPaper00059932:cnd-1(ju29)_upregulated
    Microarray_results (18)
    Expression_cluster (159)
    Interaction (102)
  Map_info: Map: III Position: -1.85688 Error: 0.001135
    Positive: Positive_clone: C34E10 Inferred_automatically: From sequence, transcript, pseudogene data
        ZC129
    Mapping_data: 2_point: 7160
      Multi_point: 4094
      Pos_neg_data: 10730
  Reference (38)
  Remark: Postitive method is cosmid rescue Paper_evidence: WBPaper00004409
  Method: Gene