WormBase Tree Display for Gene: WBGene00000561
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| WBGene00000561 | Evidence | Paper_evidence | WBPaper00004409 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C34E10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cnd-1 | Person_evidence | WBPerson105 | |||||
| WBPerson293 | |||||||||
| Sequence_name | C34E10.7 | ||||||||
| Molecular_name | C34E10.7 | ||||||||
| C34E10.7.1 | |||||||||
| CE01187 | |||||||||
| Other_name | hlh-5 | Person_evidence | WBPerson346 | ||||||
| C34E10.d | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| C34E10 | Paper_evidence | WBPaper00027608 | |||||||
| CeND | Paper_evidence | WBPaper00027608 | |||||||
| CELE_C34E10.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | cnd-1 | ||||||||
| DB_info | Database | AceView | gene | 3G328 | |||||
| WormQTL | gene | WBGene00000561 | |||||||
| WormFlux | gene | WBGene00000561 | |||||||
| OMIM | disease | 125853 | |||||||
| 606394 | |||||||||
| gene | 601724 | ||||||||
| 601725 | |||||||||
| NDB | locus_tag | CELE_C34E10.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000561|UniProtKB=P46581 | |||||||
| family | PTHR19290 | ||||||||
| NCBI | gene | 183212 | |||||||
| RefSeq | protein | NM_001392092.1 | |||||||
| SwissProt | UniProtAcc | P46581 | |||||||
| UniProt_GCRP | UniProtAcc | P46581 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cnd | ||||||||
| Allele (58) | |||||||||
| Strain | WBStrain00029627 | ||||||||
| WBStrain00029628 | |||||||||
| WBStrain00036693 | |||||||||
| WBStrain00036763 | |||||||||
| WBStrain00005364 | |||||||||
| WBStrain00029967 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (57) | |||||||||
| Paralog | WBGene00001957 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00003595 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00001953 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WBGene00001960 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00001961 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003018 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009540 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013665 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cnd-1 encodes a basic helix-loop-helix protein that is most closely related to the vertebrate NeuroD transcription factors; during development, CND-1 is predicted to function as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding; CND-1::GFP expression begins in early embryogenesis (<20 cells) in four AB descendants and then continues in mitotically active AB-derived neuronal precursors, unidentified nuclei during gastrulation and enclosure, and postmitotic neurons in the head and ventral cord; at hatching CND-1::GFP expression is visible in ventral cord neurons, but this expression disappears completely by the end of the first larval stage; CND-1::GFP does not appear to be expressed in any non-neuronal ectodermal cells, as its expression does not overlap with that of LIN-26. | Paper_evidence | WBPaper00004409 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 11 May 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in axonal fasciculation and negative regulation of gliogenesis. Located in nucleus. Expressed in several structures, including ABalpapaa; ABalppapa; motor neurons; neuroblasts; and somatic nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72; glucose metabolism disease (multiple); and obesity. Is an ortholog of several human genes including NEUROD1 (neuronal differentiation 1); NEUROD2 (neuronal differentiation 2); and NEUROD4 (neuronal differentiation 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||
| DOID:4195 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
| DOID:10603 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
| DOID:0111104 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7762) | ||||||
| DOID:0112208 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7763) | ||||||
| Disease_relevance | In humans, mutations in Neurogenic Differentiation 1 (NeuroD1) have been implicated in Diabetes Mellitus, Type II and Maturity-onset diabetes of the young, type VI; in elegans, cnd-1, seems to have combined the function of several vertebrate neurogenic bHLH proteins, and is required for the proper fate specification and terminal differentiation of motor neurons. | Homo sapiens | Paper_evidence | WBPaper00004409 | |||||
| Accession_evidence | OMIM | 606394 | |||||||
| 125853 | |||||||||
| 601724 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Sep 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C34E10.7 | |||||||
| Corresponding_transcript | C34E10.7.1 | ||||||||
| Other_sequence | Dviv_isotig35392 | ||||||||
| Dviv_isotig31167 | |||||||||
| JI178639.1 | |||||||||
| Tcol_isotig15910 | |||||||||
| Associated_feature | WBsf651039 | ||||||||
| WBsf666900 | |||||||||
| WBsf978355 | |||||||||
| WBsf992340 | |||||||||
| WBsf992341 | |||||||||
| WBsf226653 | |||||||||
| Transcription_factor | WBTranscriptionFactor000076 | ||||||||
| WBTranscriptionFactor000060 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00107382 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00041895 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029528 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005521 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066068 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011606 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (18) | |||||||||
| Drives_construct | WBCnstr00004609 | ||||||||
| WBCnstr00004610 | |||||||||
| WBCnstr00004611 | |||||||||
| WBCnstr00013822 | |||||||||
| WBCnstr00015211 | |||||||||
| WBCnstr00015212 | |||||||||
| WBCnstr00015213 | |||||||||
| WBCnstr00037451 | |||||||||
| WBCnstr00042892 | |||||||||
| WBCnstr00042894 | |||||||||
| Construct_product | WBCnstr00013822 | ||||||||
| WBCnstr00015371 | |||||||||
| WBCnstr00015372 | |||||||||
| WBCnstr00016754 | |||||||||
| WBCnstr00016967 | |||||||||
| WBCnstr00021504 | |||||||||
| WBCnstr00037451 | |||||||||
| Regulate_expr_cluster | WBPaper00059932:cnd-1(ju29)_downregulated | ||||||||
| WBPaper00059932:cnd-1(ju29)_upregulated | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (159) | |||||||||
| Interaction (102) | |||||||||
| Map_info | Map | III | Position | -1.85688 | Error | 0.001135 | |||
| Positive | Positive_clone | C34E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| ZC129 | |||||||||
| Mapping_data | 2_point | 7160 | |||||||
| Multi_point | 4094 | ||||||||
| Pos_neg_data | 10730 | ||||||||
| Reference | WBPaper00004409 | ||||||||
| WBPaper00005455 | |||||||||
| WBPaper00006120 | |||||||||
| WBPaper00006397 | |||||||||
| WBPaper00015656 | |||||||||
| WBPaper00017088 | |||||||||
| WBPaper00017224 | |||||||||
| WBPaper00017459 | |||||||||
| WBPaper00018453 | |||||||||
| WBPaper00019775 | |||||||||
| WBPaper00022122 | |||||||||
| WBPaper00022152 | |||||||||
| WBPaper00022794 | |||||||||
| WBPaper00024719 | |||||||||
| WBPaper00027299 | |||||||||
| WBPaper00027309 | |||||||||
| WBPaper00027608 | |||||||||
| WBPaper00028150 | |||||||||
| WBPaper00028984 | |||||||||
| WBPaper00031983 | |||||||||
| WBPaper00034710 | |||||||||
| WBPaper00034761 | |||||||||
| WBPaper00037020 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039730 | |||||||||
| WBPaper00043594 | |||||||||
| WBPaper00047143 | |||||||||
| WBPaper00047936 | |||||||||
| WBPaper00052395 | |||||||||
| WBPaper00052430 | |||||||||
| WBPaper00052496 | |||||||||
| WBPaper00052676 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00057866 | |||||||||
| WBPaper00059932 | |||||||||
| WBPaper00059989 | |||||||||
| WBPaper00061738 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Postitive method is cosmid rescue | Paper_evidence | WBPaper00004409 | ||||||
| Method | Gene |
