WormBase Tree Display for Gene: WBGene00000553
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| WBGene00000553 | SMap | S_parent | Sequence | K07A9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cmk-1 | Person_evidence | WBPerson321 | |||||
| Sequence_name | K07A9.2 | ||||||||
| Molecular_name | K07A9.2 | ||||||||
| K07A9.2.1 | |||||||||
| CE25046 | |||||||||
| Other_name | Ce-CaM-KI | ||||||||
| CELE_K07A9.2 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | cmk-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cmk | ||||||||
| Allele (233) | |||||||||
| Strain | WBStrain00001523 | ||||||||
| WBStrain00001522 | |||||||||
| WBStrain00031132 | |||||||||
| WBStrain00035593 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; when expressed in COS-7 cells, CMK-1 and CKK-1 positively regulate the transcriptional activity of endogenous CREB; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; in the AFD neurons, CMK-1 localizes exclusively to the cytoplasm, however when expressed in COS-7 cells, CMK-1 is seen in the nucleus. | Paper_evidence | WBPaper00003625 | |||||
| WBPaper00006343 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 07 Aug 2008 00:00:00 | ||||||||
| Automated_description | Enables calmodulin binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including neuron projection morphogenesis; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Located in cytoplasm and nucleus. Expressed in neurons and vulval muscle. Is an ortholog of human CAMK1 (calcium/calmodulin dependent protein kinase I). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | K07A9.2 | |||||||
| Corresponding_transcript | K07A9.2.1 | ||||||||
| Other_sequence (51) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00076550 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00028247 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050106 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016690 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001362 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002311 | ||||||||
| WBCnstr00004304 | |||||||||
| WBCnstr00011898 | |||||||||
| WBCnstr00019741 | |||||||||
| WBCnstr00020396 | |||||||||
| WBCnstr00040054 | |||||||||
| WBCnstr00041221 | |||||||||
| Construct_product | WBCnstr00020396 | ||||||||
| WBCnstr00038439 | |||||||||
| WBCnstr00038440 | |||||||||
| WBCnstr00038441 | |||||||||
| WBCnstr00038442 | |||||||||
| WBCnstr00041725 | |||||||||
| Antibody | WBAntibody00001944 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (167) | |||||||||
| Interaction (98) | |||||||||
| Anatomy_function | WBbtf0255 | ||||||||
| WBbtf0257 | |||||||||
| WBbtf0849 | |||||||||
| WBbtf0851 | |||||||||
| WBbtf0852 | |||||||||
| WBbtf0853 | |||||||||
| Map_info | Map | IV | Position | -15.5812 | Error | 0.282767 | |||
| Positive | Positive_clone | K07A9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4229 | |||||||
| Pseudo_map_position | |||||||||
| Reference (57) | |||||||||
| Remark | Sequence connection was previously incorrect (connected to K09A7.2) [krb 030423] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
