| WBGene00000553 | SMap | S_parent | Sequence | K07A9 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | cmk-1 | Person_evidence | WBPerson321 |
| | | Sequence_name | K07A9.2 |
| | | Molecular_name | K07A9.2 |
| | | | K07A9.2.1 |
| | | | CE25046 |
| | | Other_name | Ce-CaM-KI |
| | | | CELE_K07A9.2 | Accession_evidence | NDB | BX284604 |
| | | Public_name | cmk-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cmk |
| | Allele (233) |
| | Strain | WBStrain00001523 |
| | | WBStrain00001522 |
| | | WBStrain00031132 |
| | | WBStrain00035593 |
| | RNASeq_FPKM (74) |
| | GO_annotation (29) |
| | Ortholog (44) |
| | Paralog (17) |
| | Structured_description | Concise_description | cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; when expressed in COS-7 cells, CMK-1 and CKK-1 positively regulate the transcriptional activity of endogenous CREB; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; in the AFD neurons, CMK-1 localizes exclusively to the cytoplasm, however when expressed in COS-7 cells, CMK-1 is seen in the nucleus. | Paper_evidence | WBPaper00003625 |
| | | | | | WBPaper00006343 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 07 Aug 2008 00:00:00 |
| | | Automated_description | Enables calmodulin binding activity and calmodulin-dependent protein kinase activity. Involved in several processes, including neuron projection morphogenesis; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Located in cytoplasm and nucleus. Expressed in neurons and vulval muscle. Is an ortholog of human CAMK1 (calcium/calmodulin dependent protein kinase I). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | K07A9.2 |
| | Corresponding_transcript | K07A9.2.1 |
| | Other_sequence (51) |
| | Associated_feature (20) |
| Experimental_info | RNAi_result | WBRNAi00076550 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00028247 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00050106 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00016690 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001362 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00002311 |
| | | WBCnstr00004304 |
| | | WBCnstr00011898 |
| | | WBCnstr00019741 |
| | | WBCnstr00020396 |
| | | WBCnstr00040054 |
| | | WBCnstr00041221 |
| | Construct_product | WBCnstr00020396 |
| | | WBCnstr00038439 |
| | | WBCnstr00038440 |
| | | WBCnstr00038441 |
| | | WBCnstr00038442 |
| | | WBCnstr00041725 |
| | Antibody | WBAntibody00001944 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00006195:azacoprostane_upregulated |
| | | WBPaper00029359_1166 |
| | | WBPaper00029359_1194 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1240 |
| | | WBPaper00029359_1243 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1336 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00031011:calmodulin_binding_protein |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_CoreEnriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040412:germline-regulated_daf-12_target |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050163:let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:male-CEM-neurons_expressed |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057136:yap-1(ys38)_upregulated |
| | | WBPaper00057265:metaformin_downregulated_OP50-MR |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ASK |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AWA |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:Neuroblast_AIZ_FLP |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:SMD |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:AFD_enriched |
| | | WBPaper00061651:AVA_enriched |
| | | WBPaper00061651:BDU_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:20_0 |
| | | WBPaper00065841:80_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_14 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00027111:rde-3(r459)_upregulated |
| | | WBPaper00027111:rrf-1(pk1417)_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00042274:tbx-2(bx59)_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | Interaction (98) |
| | Anatomy_function | WBbtf0255 |
| | | WBbtf0257 |
| | | WBbtf0849 |
| | | WBbtf0851 |
| | | WBbtf0852 |
| | | WBbtf0853 |
| Map_info | Map | IV | Position | -15.5812 | Error | 0.282767 |
| | Positive | Positive_clone | K07A9 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4229 |
| | Pseudo_map_position |
| Reference (57) |
| Remark | Sequence connection was previously incorrect (connected to K09A7.2) [krb 030423] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
