WormBase Tree Display for Gene: WBGene00000545
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| WBGene00000545 | SMap | S_parent | Sequence | Y39A3CL | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | clp-4 | Person_evidence | WBPerson349 | |||||
| Sequence_name | Y39A3CL.5 | ||||||||
| Molecular_name | Y39A3CL.5a | ||||||||
| Y39A3CL.5a.1 | |||||||||
| CE33219 | |||||||||
| Other_name | CELE_Y39A3CL.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | clp-4 | ||||||||
| DB_info | Database | AceView | gene | 3C898 | |||||
| WormQTL | gene | WBGene00000545 | |||||||
| WormFlux | gene | WBGene00000545 | |||||||
| NDB | locus_tag | CELE_Y39A3CL.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000545|UniProtKB=Q8IAA9 | |||||||
| family | PTHR10183 | ||||||||
| NCBI | gene | 175326 | |||||||
| RefSeq | protein | NM_065059.10 | |||||||
| TrEMBL | UniProtAcc | Q8IAA9 | |||||||
| UniProt_GCRP | UniProtAcc | Q8IAA9 | |||||||
| OMIM | gene | 114220 | |||||||
| 114240 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clp | ||||||||
| Allele (292) | |||||||||
| Strain | WBStrain00032805 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | clp-4 encodes a large calpain subunit that is homologous to Drosophila CalpainB and the mammalian muscle-specific Calpain 3 proteins (OMIM:114240, mutations are associated with limb-girdle muscular dystrophy); by homology, CLP-4 is predicted to function as a nonlysosomal, calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-4 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-4 in C. elegans development and/or behavior is not yet known. | Paper_evidence | WBPaper00004403 | |||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in GABAergic neurons; body wall musculature; dorsal nerve cord; and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1476,HGNC:1479) | ||||
| DOID:0110275 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:0110273 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1486) | ||||||
| DOID:0110821 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1476) | ||||||
| Molecular_info | Corresponding_CDS | Y39A3CL.5a | |||||||
| Corresponding_CDS_history | Y39A3CL.5b:wp282 | ||||||||
| Corresponding_transcript | Y39A3CL.5a.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr10018 | ||||||||
| Expr1014965 | |||||||||
| Expr1030326 | |||||||||
| Expr1159658 | |||||||||
| Expr2010246 | |||||||||
| Expr2028488 | |||||||||
| Drives_construct | WBCnstr00014643 | ||||||||
| Construct_product | WBCnstr00014652 | ||||||||
| WBCnstr00014658 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (206) | |||||||||
| Interaction (22) | |||||||||
| Map_info | Map | III | Position | -16.0584 | Error | 0.022067 | |||
| Positive | Positive_clone | Y39A3CL | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005513 | ||||||||
| WBPaper00025192 | |||||||||
| WBPaper00027531 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065924 | |||||||||
| Remark | Sequence connection from [Kuwabara PE] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
