WormBase Tree Display for Gene: WBGene00000545

WBGene00000545 SMap: S_parent: Sequence: Y39A3CL
  Identity: Version: 1
    Name: CGC_name: clp-4 Person_evidence: WBPerson349
      Sequence_name: Y39A3CL.5
      Molecular_name: Y39A3CL.5a
        Y39A3CL.5a.1
        CE33219
      Other_name: CELE_Y39A3CL.5 Accession_evidence: NDB BX284603
      Public_name: clp-4
    DB_info: Database: AceView gene 3C898
        WormQTL gene WBGene00000545
        WormFlux gene WBGene00000545
        NDB locus_tag CELE_Y39A3CL.5
        Panther gene CAEEL|WormBase=WBGene00000545|UniProtKB=Q8IAA9
          family PTHR10183
        NCBI gene 175326
        RefSeq protein NM_065059.10
        TrEMBL UniProtAcc Q8IAA9
        UniProt_GCRP UniProtAcc Q8IAA9
        OMIM gene 114220
            114240
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clp
    Allele: WBVar01961927
      WBVar00042473
      WBVar01961928
      WBVar02145013
      WBVar01961929
      WBVar01565214
      WBVar00042478
      WBVar01961930
      WBVar01565215
      WBVar01961931
      WBVar01898662
      WBVar01565216
      WBVar00042483
      WBVar01793145
      WBVar00042488
      WBVar01793146
      WBVar01793147
      WBVar01793148
      WBVar00042493
      WBVar01793149
      WBVar01793150
      WBVar01793151
      WBVar01500082
      WBVar00042498
      WBVar01692255
      WBVar01692256
      WBVar01407699
      WBVar00042503
      WBVar01721977
      WBVar01407701
      WBVar01606859
      WBVar01721978
      WBVar01606860
      WBVar01606861
      WBVar00042508
      WBVar01721979
      WBVar01606862
      WBVar01721980
      WBVar01606863
      WBVar01721981
      WBVar00042513
      WBVar01903660
      WBVar00042518
      WBVar01770665
      WBVar02018612
      WBVar01770666
      WBVar02018613
      WBVar01770667
      WBVar01770668
      WBVar02081628
      WBVar02094141
      WBVar01770669
      WBVar01770670
      WBVar01770671
      WBVar01498832
      WBVar02014867
      WBVar01507319
      WBVar01507320
      WBVar01983744
      WBVar02099491
      WBVar01507321
      WBVar01983745
      WBVar02099492
      WBVar01507322
      WBVar01983746
      WBVar01507323
      WBVar01983747
      WBVar02036179
      WBVar00560813
      WBVar01983748
      WBVar00560814
      WBVar01983749
      WBVar02036180
      WBVar02036181
      WBVar00560823
      WBVar00560824
      WBVar02036182
      WBVar00560825
      WBVar00093905
      WBVar00560830
      WBVar00560831
      WBVar02072341
      WBVar01395985
      WBVar01708192
      WBVar01686238
      WBVar01395986
      WBVar01708193
      WBVar01686239
      WBVar01994635
      WBVar01686240
      WBVar01708194
      WBVar01708195
      WBVar01686241
      WBVar01708196
      WBVar01686242
      WBVar02007456
      WBVar01708197
      WBVar02089581
      WBVar02055696
      WBVar02110008
      WBVar02095840
      WBVar02012834
      WBVar02103206
      WBVar02012835
      WBVar00305302
      WBVar02151159
      WBVar00300925
      WBVar00805848
      WBVar00805849
      WBVar00805850
      WBVar01401260
      WBVar00805851
      WBVar00805852
      WBVar00805853
      WBVar00805854
      WBVar00805855
      WBVar00805856
      WBVar01326041
      WBVar01326042
      WBVar00805857
      WBVar00805858
      WBVar01326043
      WBVar01326044
      WBVar00805859
      WBVar00805860
      WBVar01326045
      WBVar00042363
      WBVar01326052
      WBVar00805861
      WBVar01326054
      WBVar00805862
      WBVar01326060
      WBVar02071648
      WBVar00805863
      WBVar01326062
      WBVar00042368
      WBVar00805864
      WBVar00805865
      WBVar01326066
      WBVar00805866
      WBVar01415439
      WBVar01846721
      WBVar00042373
      WBVar00805867
      WBVar00805868
      WBVar00805869
      WBVar00042378
      WBVar00805870
      WBVar00805871
      WBVar00390701
      WBVar00805872
      WBVar00390702
      WBVar00390703
      WBVar00042383
      WBVar00805873
      WBVar00390704
      WBVar00805874
      WBVar00390705
      WBVar00805875
      WBVar00390706
      WBVar00042388
      WBVar00805876
      WBVar00390707
      WBVar00805877
      WBVar01479226
      WBVar00390708
      WBVar00805878
      WBVar00805879
      WBVar00042393
      WBVar00390709
      WBVar01951523
      WBVar01578543
      WBVar02075590
      WBVar00390710
      WBVar01578544
      WBVar00805880
      WBVar01951524
      WBVar00390711
      WBVar00805881
      WBVar01951525
      WBVar01951526
      WBVar00390712
      WBVar00805882
      WBVar00042398
      WBVar00390713
      WBVar00805883
      WBVar00390714
      WBVar00805884
      WBVar00805885
      WBVar00042403
      WBVar00390715
      WBVar00805886
      WBVar00390716
      WBVar00805887
      WBVar00390717
      WBVar00805888
      WBVar00042408
      WBVar00390718
      WBVar00390719
      WBVar00805889
      WBVar00390720
      WBVar00805890
      WBVar00805891
      WBVar00390721
      WBVar00042413
      WBVar00805892
      WBVar00390722
      WBVar00390723
      WBVar00805893
      WBVar00390724
      WBVar00805894
      WBVar00021851
      WBVar01258274
      WBVar00805895
      WBVar00042423
      WBVar00805896
      WBVar01258275
      WBVar00805897
      WBVar01258276
      WBVar00021856
      WBVar00805898
      WBVar01258277
      WBVar00042428
      WBVar01258280
      WBVar00805899
      WBVar01258281
      WBVar00805900
      WBVar01258283
      WBVar00805901
      WBVar00042433
      WBVar00805902
      WBVar01258288
      WBVar00805903
      WBVar00805904
      WBVar01258289
      WBVar00021866
      WBVar01258290
      WBVar01918315
      WBVar00805905
      WBVar00042438
      WBVar00805906
      WBVar01918316
      WBVar01258292
      WBVar00805907
      WBVar01258294
      WBVar00021871
      WBVar01918317
      WBVar02146811
      WBVar01918319
      WBVar00805908
      WBVar00042443
      WBVar00805909
      WBVar01258298
      WBVar00021876
      WBVar01258299
      WBVar00805910
      WBVar01258300
      WBVar00805911
      WBVar00042448
      WBVar00805912
      WBVar01258303
      WBVar00805913
      WBVar00021881
      WBVar01258307
      WBVar00042453
      WBVar00805914
      WBVar00601212
      WBVar00805915
      WBVar01258308
      WBVar01258312
      WBVar00805916
      WBVar00096847
      WBVar00042458
      WBVar00096849
      WBVar00805917
      WBVar01258314
      WBVar00805918
      WBVar00096850
      WBVar01258316
      WBVar00805919
      WBVar00096851
      WBVar00805920
      WBVar01443915
      WBVar00042463
      WBVar00805921
      WBVar01443918
      WBVar00805922
      WBVar00042468
      WBVar00805923
      WBVar01961925
      WBVar00255044
      WBVar01961926
    Strain: WBStrain00032805
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (47)
    Paralog (13)
    Structured_description: Concise_description: clp-4 encodes a large calpain subunit that is homologous to Drosophila CalpainB and the mammalian muscle-specific Calpain 3 proteins (OMIM:114240, mutations are associated with limb-girdle muscular dystrophy); by homology, CLP-4 is predicted to function as a nonlysosomal, calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-4 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-4 in C. elegans development and/or behavior is not yet known. Paper_evidence: WBPaper00004403
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in GABAergic neurons; body wall musculature; dorsal nerve cord; and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1476,HGNC:1479)
      DOID:0110275 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1480)
      DOID:0110273 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1480)
      DOID:9884 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1480)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1486)
      DOID:0110821 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1476)
  Molecular_info: Corresponding_CDS: Y39A3CL.5a
    Corresponding_CDS_history: Y39A3CL.5b:wp282
    Corresponding_transcript: Y39A3CL.5a.1
    Other_sequence (12)
    Associated_feature (11)
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr10018
      Expr1014965
      Expr1030326
      Expr1159658
      Expr2010246
      Expr2028488
    Drives_construct: WBCnstr00014643
    Construct_product: WBCnstr00014652
      WBCnstr00014658
    Microarray_results (22)
    Expression_cluster (206)
    Interaction (22)
  Map_info: Map: III Position: -16.0584 Error: 0.022067
    Positive: Positive_clone: Y39A3CL Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005513
    WBPaper00025192
    WBPaper00027531
    WBPaper00038491
    WBPaper00055090
    WBPaper00065924
  Remark: Sequence connection from [Kuwabara PE]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene