WormBase Tree Display for Gene: WBGene00000539
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| WBGene00000539 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F07B10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | cln-3.1 | |||||||
| Sequence_name | F07B10.1 | ||||||||
| Molecular_name | F07B10.1a | ||||||||
| F07B10.1a.1 | |||||||||
| CE09198 | |||||||||
| F07B10.1b | |||||||||
| CE46158 | |||||||||
| F07B10.1b.1 | |||||||||
| Other_name | CELE_F07B10.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | cln-3.1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cln | ||||||||
| Allele (38) | |||||||||
| Strain | WBStrain00003257 | ||||||||
| WBStrain00028940 | |||||||||
| WBStrain00032172 | |||||||||
| WBStrain00040679 | |||||||||
| WBStrain00040680 | |||||||||
| WBStrain00040682 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00000540 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00007586 | |||||||||
| WBGene00000541 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Automated_description | Involved in determination of adult lifespan and regulation of egg-laying behavior. Located in cytoplasm. Expressed in cuticle; diagonal muscle; hypodermis; intestine; and pharynx. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Is an ortholog of human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14503 | Homo sapiens | Paper_evidence | WBPaper00027030 | ||||
| Accession_evidence | OMIM | 204200 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 May 2017 00:00:00 | ||||||||
| Potential_model | DOID:0110731 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2074) | |||||
| Models_disease_asserted | WBDOannot00000119 | ||||||||
| WBDOannot00000314 | |||||||||
| Molecular_info | Corresponding_CDS | F07B10.1a | |||||||
| F07B10.1b | |||||||||
| Corresponding_transcript | F07B10.1a.1 | ||||||||
| F07B10.1b.1 | |||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf234521 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00043854 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030592 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram53 | ||||||||
| Expr3817 | |||||||||
| Expr3818 | |||||||||
| Expr3819 | |||||||||
| Expr5669 | |||||||||
| Expr1023637 | |||||||||
| Expr1147829 | |||||||||
| Expr2010240 | |||||||||
| Expr2028482 | |||||||||
| Drives_construct | WBCnstr00003732 | ||||||||
| WBCnstr00011674 | |||||||||
| WBCnstr00037464 | |||||||||
| Construct_product | WBCnstr00037464 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (180) | |||||||||
| Interaction | WBInteraction000122588 | ||||||||
| WBInteraction000133974 | |||||||||
| WBInteraction000133975 | |||||||||
| WBInteraction000285465 | |||||||||
| WBInteraction000319652 | |||||||||
| WBInteraction000391919 | |||||||||
| WBInteraction000415645 | |||||||||
| Map_info | Map | V | Position | 3.03495 | Error | 0.0019 | |||
| Positive | Positive_clone | F01B10 | |||||||
| F07B10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4225 | |||||||
| 4365 | |||||||||
| 4855 | |||||||||
| 4822 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | [Sara E Mole] Three C. elegans genes are equally similar to the human gene CLN3 which causes juvenile neuronal ceroid lipofuscinosis (NCL) or Batten disease. There is at least one similar gene in over 20 eukaryotic species, including S. cerevisiae, S.pombe, D. melanogaster. No other completely sequenced genome has more than one CLN3 homologue. All three cln-3 genes in C. elegans are trancribed and accession numbers have been applied for. In human there are up to 8 NCL genes named CLN-8. CLN1 also has one homologue in C. elegans. CLN1 encodes the enzyme palmitoyl protein thioesterase 1 (PPT1). | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
