WormBase Tree Display for Gene: WBGene00000539

WBGene00000539 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F07B10
  Identity: Version: 1
    Name: CGC_name: cln-3.1
      Sequence_name: F07B10.1
      Molecular_name: F07B10.1a
        F07B10.1a.1
        CE09198
        F07B10.1b
        CE46158
        F07B10.1b.1
      Other_name: CELE_F07B10.1 Accession_evidence: NDB BX284605
      Public_name: cln-3.1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cln
    Allele (38)
    Strain: WBStrain00003257
      WBStrain00028940
      WBStrain00032172
      WBStrain00040679
      WBStrain00040680
      WBStrain00040682
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00071127 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00041560 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00093125 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00124234 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00140702 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00126355 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00084201 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00303153 Caenorhabditis briggsae From_analysis: WormBase-Compara
      WBGene00227619 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g65 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g1495 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g10821 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g14979 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g1506 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g23570 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g14354 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g686 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g11729 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g13520 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g26941 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g8707 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g3547 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00637.g13021 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_03701.g18303 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-cln-3.1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold495.g2181 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00394.g10693 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_16525 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_016680 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06260 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g14805 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g11001 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g11002 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g11003 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50317100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g15728 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237740 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00263067 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000003595 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0036756 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-041114-174 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2074 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:107537 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1359537 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00000540 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00007586
      WBGene00000541 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Automated_description: Involved in determination of adult lifespan and regulation of egg-laying behavior. Located in cytoplasm. Expressed in cuticle; diagonal muscle; hypodermis; intestine; and pharynx. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Is an ortholog of human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14503 Homo sapiens Paper_evidence: WBPaper00027030
          Accession_evidence: OMIM 204200
          Curator_confirmed: WBPerson324
          Date_last_updated: 08 May 2017 00:00:00
    Potential_model: DOID:0110731 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2074)
  Models_disease_asserted: WBDOannot00000119
    WBDOannot00000314
  Molecular_info: Corresponding_CDS: F07B10.1a
      F07B10.1b
    Corresponding_transcript: F07B10.1a.1
      F07B10.1b.1
    Other_sequence (13)
    Associated_feature: WBsf234521
  Experimental_info: RNAi_result: WBRNAi00043854 Inferred_automatically: RNAi_primary
      WBRNAi00030592 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram53
      Expr3817
      Expr3818
      Expr3819
      Expr5669
      Expr1023637
      Expr1147829
      Expr2010240
      Expr2028482
    Drives_construct: WBCnstr00003732
      WBCnstr00011674
      WBCnstr00037464
    Construct_product: WBCnstr00037464
    Microarray_results (19)
    Expression_cluster (180)
    Interaction: WBInteraction000122588
      WBInteraction000133974
      WBInteraction000133975
      WBInteraction000285465
      WBInteraction000319652
      WBInteraction000391919
      WBInteraction000415645
  Map_info: Map: V Position: 3.03495 Error: 0.0019
    Positive: Positive_clone: F01B10
        F07B10 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4225
        4365
        4855
        4822
    Pseudo_map_position
  Reference (11)
  Remark: [Sara E Mole] Three C. elegans genes are equally similar to the human gene CLN3 which causes juvenile neuronal ceroid lipofuscinosis (NCL) or Batten disease. There is at least one similar gene in over 20 eukaryotic species, including S. cerevisiae, S.pombe, D. melanogaster. No other completely sequenced genome has more than one CLN3 homologue. All three cln-3 genes in C. elegans are trancribed and accession numbers have been applied for. In human there are up to 8 NCL genes named CLN-8. CLN1 also has one homologue in C. elegans. CLN1 encodes the enzyme palmitoyl protein thioesterase 1 (PPT1).
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene