WormBase Tree Display for Gene: WBGene00000491
expand all nodes | collapse all nodes | view schema
WBGene00000491 | SMap | S_parent | Sequence | B0024 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | che-12 | Paper_evidence | WBPaper00031483 | |||||
Person_evidence | WBPerson261 | ||||||||
Sequence_name | B0024.8 | ||||||||
Molecular_name (12) | |||||||||
Other_name | CELE_B0024.8 | Accession_evidence | NDB | BX284605 | |||||
Public_name | che-12 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 20 Feb 2008 17:02:59 | WBPerson2970 | Event | Acquires_merge | WBGene00007098 | ||||
Name_change | Sequence_name | B0024.8 | |||||||
Acquires_merge | WBGene00007098 | ||||||||
WBGene00043072 | |||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | che | ||||||||
Reference_allele | WBVar00144323 | ||||||||
Allele (105) | |||||||||
Legacy_information | e1812 : weak FITC uptake by amphids and phasmids; amphid sheath cells fail to secrete matrix material; defective osmotic avoidance. ES1 ME3. NA1. | ||||||||
See also e1812, e1813 | |||||||||
[C.elegansII] e1812 : Dyf (weak FITC uptake by amphids and phasmids); amphid sheath cells fail to secrete matrix material; defective osmotic avoidance. ES1 ME3. OA3: e1813, mn389, mn399. [Perkins et al. 1986; Starich et al. 1995] | |||||||||
Strain | WBStrain00034365 | ||||||||
WBStrain00034375 | |||||||||
WBStrain00004477 | |||||||||
WBStrain00024211 | |||||||||
WBStrain00024215 | |||||||||
WBStrain00024210 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (41) | |||||||||
Paralog | WBGene00015580 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00000549 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00013847 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | che-12 encodes a conserved protein orthologous to the mammalian protein Crescerin1 encoded by the gene FAM179B (KIAA0423); CHE-12 activity is required continuously in sensory neurons for formation of distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis to a subset of attractants, including sodium chloride; CHE-12 contains four TOG domains whose tubulin-binding activity is essential for proper cilia structure and function; a che-12::gfp promoter fusion is expressed in the two phasmid neurons and the subset of amphid neurons that contain relatively simple cilia; a CHE-12::GFP protein localizes to cilia in a manner suggesting that it requires intraflagellar transport for proper localization, but is unlikely to be a core IFT particle component; che-12 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor. | Paper_evidence | WBPaper00000932 | |||||
WBPaper00004404 | |||||||||
WBPaper00031483 | |||||||||
WBPaper00048578 | |||||||||
Person_evidence | WBPerson31209 | ||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 02 Oct 2015 00:00:00 | ||||||||
Automated_description | Predicted to enable microtubule binding activity. Involved in several processes, including chemotaxis; cilium assembly; and hyperosmotic response. Located in cilium; dendrite; and neuronal cell body. Expressed in amphid neurons and phasmid neurons. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Joubert syndrome. Is an ortholog of human TOGARAM1 (TOG array regulator of axonemal microtubules 1) and TOGARAM2 (TOG array regulator of axonemal microtubules 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:0060340 | Homo sapiens | Paper_evidence | WBPaper00060234 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 27 Jul 2022 00:00:00 | ||||||||
Potential_model | DOID:0050777 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19959) | |||||
Models_disease_asserted | WBDOannot00001295 | ||||||||
Molecular_info | Corresponding_CDS | B0024.8a | |||||||
B0024.8b | |||||||||
B0024.8c | |||||||||
B0024.8d | |||||||||
Corresponding_CDS_history | B0024.8:wp193 | ||||||||
Corresponding_transcript | B0024.8a.1 | ||||||||
B0024.8b.1 | |||||||||
B0024.8c.1 | |||||||||
B0024.8d.1 | |||||||||
Other_sequence | JO472975.1 | ||||||||
JI167894.1 | |||||||||
JI220115.1 | |||||||||
Dviv_isotig24781 | |||||||||
Acan_isotig10962 | |||||||||
JI466984.1 | |||||||||
Associated_feature | WBsf668674 | ||||||||
WBsf669297 | |||||||||
WBsf669298 | |||||||||
WBsf669299 | |||||||||
WBsf1001090 | |||||||||
WBsf1001091 | |||||||||
WBsf1001092 | |||||||||
WBsf1020294 | |||||||||
WBsf1020295 | |||||||||
Experimental_info | RNAi_result | WBRNAi00009552 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009554 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027946 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038655 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038656 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr8175 | ||||||||
Expr12476 | |||||||||
Expr1016192 | |||||||||
Expr1030289 | |||||||||
Expr1142862 | |||||||||
Expr2009961 | |||||||||
Expr2028201 | |||||||||
Drives_construct | WBCnstr00013160 | ||||||||
WBCnstr00017235 | |||||||||
Construct_product | WBCnstr00013160 | ||||||||
Microarray_results (23) | |||||||||
Expression_cluster (176) | |||||||||
Interaction | WBInteraction000503479 | ||||||||
WBProcess | WBbiopr:00000025 | ||||||||
Map_info | Map | V | Position | 2.45564 | Error | 0.002725 | |||
Positive | Positive_clone | B0024 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 791 | |||||||
Multi_point | 723 | ||||||||
1173 | |||||||||
3064 | |||||||||
3065 | |||||||||
3066 | |||||||||
Pos_neg_data | 8319 | ||||||||
Reference | WBPaper00000932 | ||||||||
WBPaper00001704 | |||||||||
WBPaper00001705 | |||||||||
WBPaper00001786 | |||||||||
WBPaper00001854 | |||||||||
WBPaper00002087 | |||||||||
WBPaper00002967 | |||||||||
WBPaper00003680 | |||||||||
WBPaper00006052 | |||||||||
WBPaper00006516 | |||||||||
WBPaper00010657 | |||||||||
WBPaper00027264 | |||||||||
WBPaper00029015 | |||||||||
WBPaper00029016 | |||||||||
WBPaper00031483 | |||||||||
WBPaper00032078 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00048578 | |||||||||
WBPaper00049337 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00055368 | |||||||||
WBPaper00060234 | |||||||||
WBPaper00062984 | |||||||||
WBPaper00064660 | |||||||||
Method | Gene |