WormBase Tree Display for Gene: WBGene00000443
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| WBGene00000443 | SMap | S_parent | Sequence | F31E3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ceh-20 | Person_evidence | WBPerson83 | |||||
| Sequence_name | F31E3.1 | ||||||||
| Molecular_name | F31E3.1 | ||||||||
| F31E3.1.1 | |||||||||
| CE01241 | |||||||||
| Other_name | CELE_F31E3.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | ceh-20 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ceh | ||||||||
| Allele (47) | |||||||||
| Legacy_information | [Chen E] Vul, Egl, SM migration defects. Stronger alleles are larval lethal. Males do not mate. | ||||||||
| [C.elegansII] ay9 : Vul, Egl, SM migration defects. Stronger alleles are larval lethal, Unc,defective in Q daughter migrations, M lineage. Males do not mate, have defective tails. OA3: ay412 (severe Unc, Vul), ay37,ay38 (both larval lethal). Encodes PBC class homeoprotein. Antibody stains posterior of embryo, RVG and VNC of larva; weak staining in body muscle and hypodermis. [Burglin and Ruvkun 1992; NH; TB] | |||||||||
| Complementation_data | [Chen E] complements lin-39(n1760) fails to complement sar-3(n2513) | ||||||||
| Strain (16) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00000461 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006796 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00017690 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ceh-20 encodes one of three C. elegans homeodomain proteins (CEH-20, CEH-40, and CEH-60) homologous to Extradenticle (Exd/Pbx); together with ceh-40 and unc-62, ceh-20 activity is required for embryonic viability; ceh-20 is also required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; in addition, ceh-20 is required for regulating post-embryonic migrations of the Q neuroblast descendants and for regulating vulval development; a CEH-20::GFP fusion protein is expressed in embryos and postembryonically in many cell types including the Q, P, and V cells and their descendants; CEH-20 localizes to the nucleus. | Paper_evidence | WBPaper00004482 | |||||
| WBPaper00005629 | |||||||||
| WBPaper00025016 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 27 Jun 2011 00:00:00 | ||||||||
| Automated_description | Enables cis-regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of mesodermal cell fate specification; and regulation of asymmetric cell division. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P1.p; P2.p; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay; esophagus squamous cell carcinoma; and glaucoma. Is an ortholog of human PBX4 (PBX homeobox 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8632) | ||||
| DOID:3748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8634) | ||||||
| DOID:0112359 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8632) | ||||||
| Molecular_info | Corresponding_CDS | F31E3.1 | |||||||
| Corresponding_transcript | F31E3.1.1 | ||||||||
| Other_sequence (49) | |||||||||
| Associated_feature | WBsf654972 | ||||||||
| WBsf978284 | |||||||||
| WBsf992911 | |||||||||
| WBsf1015177 | |||||||||
| WBsf225187 | |||||||||
| Gene_product_binds (18) | |||||||||
| Transcription_factor | WBTranscriptionFactor000095 | ||||||||
| WBTranscriptionFactor000486 | |||||||||
| Experimental_info | RNAi_result (30) | ||||||||
| Expr_pattern (18) | |||||||||
| Drives_construct | WBCnstr00004632 | ||||||||
| WBCnstr00005576 | |||||||||
| WBCnstr00011239 | |||||||||
| WBCnstr00011430 | |||||||||
| WBCnstr00011699 | |||||||||
| WBCnstr00012676 | |||||||||
| WBCnstr00013523 | |||||||||
| WBCnstr00018203 | |||||||||
| WBCnstr00037534 | |||||||||
| Construct_product | WBCnstr00004632 | ||||||||
| WBCnstr00005576 | |||||||||
| WBCnstr00011239 | |||||||||
| WBCnstr00011699 | |||||||||
| WBCnstr00016053 | |||||||||
| WBCnstr00017965 | |||||||||
| WBCnstr00018045 | |||||||||
| WBCnstr00018159 | |||||||||
| WBCnstr00018203 | |||||||||
| WBCnstr00037534 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (162) | |||||||||
| Interaction (157) | |||||||||
| Map_info | Map | III | Position | -0.852634 | Error | 0.002142 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F31E3 | Person_evidence | WBPerson848 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Negative | Negative_clone | R01H2 | Person_evidence | WBPerson848 | |||||
| Mapping_data | Multi_point (6) | ||||||||
| Reference (71) | |||||||||
| Remark | homologous to human PBX1,2,3 homeobox genes | ||||||||
| cm7b3 in sequence list unneccessary. sdm 11/00 | |||||||||
| Sequence connection updated to reflect that F31E3.1 was merged into F31E3.2d. [020620 krb] | |||||||||
| Sequence connection reverted to F31E3.1 on advice on WashU curators [krb 040407] | Person_evidence | WBPerson1849 | |||||||
| Method | Gene |
