WormBase Tree Display for Gene: WBGene00000439

WBGene00000439 SMap: S_parent: Sequence: C13G5
  Identity: Version: 1
    Name: CGC_name: ceh-16 Person_evidence: WBPerson83
      Sequence_name: C13G5.1
      Molecular_name: C13G5.1
        C13G5.1.1
        CE37477
        C13G5.1.2
      Other_name: CELE_C13G5.1 Accession_evidence: NDB BX284603
      Public_name: ceh-16
    DB_info: Database: AceView gene 3J715
        WormQTL gene WBGene00000439
        WormFlux gene WBGene00000439
        NDB locus_tag CELE_C13G5.1
        Panther gene CAEEL|WormBase=WBGene00000439|UniProtKB=P34326
          family PTHR24341
        NCBI gene 191618
        RefSeq protein NM_001392158.1
        SwissProt UniProtAcc P34326
        TREEFAM TREEFAM_ID TF106461
        UniProt_GCRP UniProtAcc P34326
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ceh
    Allele (66)
    Legacy_information: [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related.[Kamb et al. 1989]
      [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related. [Kamb et al. 1989]
    Strain: WBStrain00035877
      WBStrain00003898
      WBStrain00008591
      WBStrain00049293
      WBStrain00049304
      WBStrain00055072
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (43)
    Paralog: WBGene00000462 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00007417 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: ceh-16 encodes a homeodomain protein orthologous to Drosophila and vertebrate Engrailed proteins involved in segment and appendage development; ceh-16 is an essential gene required for proper specification and differentiation of the lateral seam cells during embryonic development; in specifying seam cell fates, CEH-16 appears to act as a transcriptional regulator, repressing expression of the eff-1 gene required for cell fusion and inducing expression of seam cell-specific genes such as elt-5/GATA, nhr-73, and nhr-74; in addition, during post-embryonic development, ceh-16 functions to regulate the expansion division of the epidermal seam cells that occurs during the L2 larval stage; in regulating the expansion division, ceh-16 interacts genetically with apr-1, a member of the Wnt signaling pathway that encodes the C. elegans APC ortholog; a rescuing CEH-16::GFP fusion protein is first expressed in the early embryo in cells of the AB lineage; in later embryonic stages CEH-16::GFP is seen in all lateral seam cell nuclei as well as in some anterior neurons; during post-embryonic development, CEH-16::GFP is expressed in the DA1 and DD1 motor neurons. Paper_evidence: WBPaper00024903
            WBPaper00034732
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 03 Jan 2011 00:00:00
      Automated_description: Enables sequence-specific DNA binding activity. Involved in several processes, including embryonic body morphogenesis; epidermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ABarpa; AIZ; hyp5; retrovesicular ganglion neurons; and seam cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Is an ortholog of human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3342)
      DOID:12849 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3343)
  Molecular_info: Corresponding_CDS: C13G5.1
    Corresponding_CDS_history: C13G5.1:wp131
    Corresponding_transcript: C13G5.1.1
      C13G5.1.2
    Other_sequence (18)
    Associated_feature (8)
    Gene_product_binds: WBsf977574
      WBsf977575
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    Transcription_factor: WBTranscriptionFactor000541
  Experimental_info: RNAi_result (14)
    Expr_pattern (20)
    Drives_construct (13)
    Construct_product: WBCnstr00005599
      WBCnstr00005670
      WBCnstr00011405
      WBCnstr00013434
      WBCnstr00016073
      WBCnstr00016562
      WBCnstr00016869
      WBCnstr00019258
      WBCnstr00037538
    Antibody: WBAntibody00000835
    Microarray_results (21)
    Expression_cluster (113)
    Interaction (97)
    Anatomy_function: WBbtf0067
  Map_info: Map: III Position: -0.216271 Error: 0.001861
    Positive: Positive_clone: C13G5 Inferred_automatically: From sequence, transcript, pseudogene data
        CF#EN2
    Mapping_data: Multi_point: 5618
    Pseudo_map_position
  Reference (29)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene