WormBase Tree Display for Gene: WBGene00000439
expand all nodes | collapse all nodes | view schema
WBGene00000439 | SMap | S_parent | Sequence | C13G5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | ceh-16 | Person_evidence | WBPerson83 | |||||
Sequence_name | C13G5.1 | ||||||||
Molecular_name | C13G5.1 | ||||||||
C13G5.1.1 | |||||||||
CE37477 | |||||||||
C13G5.1.2 | |||||||||
Other_name | CELE_C13G5.1 | Accession_evidence | NDB | BX284603 | |||||
Public_name | ceh-16 | ||||||||
DB_info | Database | AceView | gene | 3J715 | |||||
WormQTL | gene | WBGene00000439 | |||||||
WormFlux | gene | WBGene00000439 | |||||||
NDB | locus_tag | CELE_C13G5.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000439|UniProtKB=P34326 | |||||||
family | PTHR24341 | ||||||||
NCBI | gene | 191618 | |||||||
RefSeq | protein | NM_001392158.1 | |||||||
SwissProt | UniProtAcc | P34326 | |||||||
TREEFAM | TREEFAM_ID | TF106461 | |||||||
UniProt_GCRP | UniProtAcc | P34326 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ceh | ||||||||
Allele (66) | |||||||||
Legacy_information | [C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related.[Kamb et al. 1989] | ||||||||
[C.elegansII] NMK. Encodes predicted homeoprotein, engrailed related. [Kamb et al. 1989] | |||||||||
Strain | WBStrain00035877 | ||||||||
WBStrain00003898 | |||||||||
WBStrain00008591 | |||||||||
WBStrain00049293 | |||||||||
WBStrain00049304 | |||||||||
WBStrain00055072 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (20) | |||||||||
Ortholog (43) | |||||||||
Paralog | WBGene00000462 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
WBGene00007417 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Structured_description | Concise_description | ceh-16 encodes a homeodomain protein orthologous to Drosophila and vertebrate Engrailed proteins involved in segment and appendage development; ceh-16 is an essential gene required for proper specification and differentiation of the lateral seam cells during embryonic development; in specifying seam cell fates, CEH-16 appears to act as a transcriptional regulator, repressing expression of the eff-1 gene required for cell fusion and inducing expression of seam cell-specific genes such as elt-5/GATA, nhr-73, and nhr-74; in addition, during post-embryonic development, ceh-16 functions to regulate the expansion division of the epidermal seam cells that occurs during the L2 larval stage; in regulating the expansion division, ceh-16 interacts genetically with apr-1, a member of the Wnt signaling pathway that encodes the C. elegans APC ortholog; a rescuing CEH-16::GFP fusion protein is first expressed in the early embryo in cells of the AB lineage; in later embryonic stages CEH-16::GFP is seen in all lateral seam cell nuclei as well as in some anterior neurons; during post-embryonic development, CEH-16::GFP is expressed in the DA1 and DD1 motor neurons. | Paper_evidence | WBPaper00024903 | |||||
WBPaper00034732 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 03 Jan 2011 00:00:00 | ||||||||
Automated_description | Enables sequence-specific DNA binding activity. Involved in several processes, including embryonic body morphogenesis; epidermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including ABarpa; AIZ; hyp5; retrovesicular ganglion neurons; and seam cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Is an ortholog of human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3342) | ||||
DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3343) | ||||||
Molecular_info | Corresponding_CDS | C13G5.1 | |||||||
Corresponding_CDS_history | C13G5.1:wp131 | ||||||||
Corresponding_transcript | C13G5.1.1 | ||||||||
C13G5.1.2 | |||||||||
Other_sequence (18) | |||||||||
Associated_feature (8) | |||||||||
Gene_product_binds (362) | |||||||||
Transcription_factor | WBTranscriptionFactor000541 | ||||||||
Experimental_info | RNAi_result (14) | ||||||||
Expr_pattern (20) | |||||||||
Drives_construct (13) | |||||||||
Construct_product | WBCnstr00005599 | ||||||||
WBCnstr00005670 | |||||||||
WBCnstr00011405 | |||||||||
WBCnstr00013434 | |||||||||
WBCnstr00016073 | |||||||||
WBCnstr00016562 | |||||||||
WBCnstr00016869 | |||||||||
WBCnstr00019258 | |||||||||
WBCnstr00037538 | |||||||||
Antibody | WBAntibody00000835 | ||||||||
Microarray_results (21) | |||||||||
Expression_cluster (113) | |||||||||
Interaction (97) | |||||||||
Anatomy_function | WBbtf0067 | ||||||||
Map_info | Map | III | Position | -0.216271 | Error | 0.001861 | |||
Positive | Positive_clone | C13G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
CF#EN2 | |||||||||
Mapping_data | Multi_point | 5618 | |||||||
Pseudo_map_position | |||||||||
Reference (29) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |