[C.elegansII] n1812 : programmmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33); Mig, hermaphrodite distal tip cells execute extra turns; extensive maternal rescue; no gross phenotype. OA1: n2002.Cloned : 5.6 kb transcript, predicted protein 180 kD, novel.[Ellis et al. 1991; MT; NF; ZB]
[C.elegansII] n1812 : programmmed cell deaths abnormal, dying cells arrest at highly refractile stage; killer cells fail to engulf target cells; engulfment group B (ced-2,5,10 : suppress vulvaless phenotype of lin-24, lin-33); Mig, hermaphrodite distal tip cells execute extra turns; extensive maternal rescue; no gross phenotype. OA1: n2002.Cloned : 5.6 kb transcript, predicted protein 180 kD, novel. [Ellis et al. 1991; MT; NF; ZB]
[Wu Y-C, Horvitz HR] Encodes 1781 aa predicted protein with similarity to human protein DOCK180. n1812 is stop at codon 28, n2002, n2691 also nonsense mutations, m2098, n2099 are splice acceptor mutations. n1812/sDf2 resemble n1812/n1812, probable null phenotype. Predicted gene C02F4.1
ced-5 encodes a homolog of the human protein DOCK180; ced-5 is required for the cell engulfment stage of programmed cell death, and physically interacts with CED-2.
Enables SH3 domain binding activity and enzyme binding activity. Involved in several processes, including left/right axis specification; positive regulation of distal tip cell migration; and vesicle-mediated transport. Located in presynapse. Part of guanyl-nucleotide exchange factor complex. Expressed in body wall muscle cell; hermaphrodite somatic gonadal cell; and intestinal cell. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and immunodeficiency 40. Is an ortholog of human DOCK2 (dedicator of cytokinesis 2) and DOCK5 (dedicator of cytokinesis 5).