WormBase Tree Display for Gene: WBGene00000406
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| WBGene00000406 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cdk-4 | Person_evidence | WBPerson346 | |||||
| Sequence_name | F18H3.5 | ||||||||
| Molecular_name | F18H3.5 | ||||||||
| F18H3.5.1 | |||||||||
| CE18608 | |||||||||
| Other_name | CELE_F18H3.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | cdk-4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cdk | ||||||||
| Allele (67) | |||||||||
| Legacy_information | [Krause MW] cdk-4 is a cyclin dependent kinase related to cdk-4 and cdk-6 from other organims. Homozygous cdk-4(gv3) animals usually arrest in L2 due to no, or limited, proliferation of the post-embryonic blast cells. About 3% of animals make it to a late stage of development. | ||||||||
| Strain | WBStrain00023588 | ||||||||
| WBStrain00034600 | |||||||||
| WBStrain00034601 | |||||||||
| WBStrain00003937 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (43) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | cdk-4 encodes two isoforms of a cyclin-dependent serine/threonine protein kinase orthologous to human CDK4 and CDK6 (OMIM:123829 and OMIM:603368, mutated in cutanous malignant melanoma) which complex with D-type cyclins to regulate progression through the G1 phase of the cell cycle; CDK-4 activity is essential for G1 progression in postembryonic blast cells and as a result, cdk-4 mutant animals generally arrest during larval stages; the lethality generated by cdk mutations, also seen in animals doubly mutant for cdk-4 and cyd-1, a C. elegans D-type cyclin, can be suppressed by mutations in lin-35/Rb suggesting that, as in other organisms, LIN-35/Rb may be a major target of CDK-4/CYD-1 kinase activity; CDK-4 expression is first detected in neuronal and hypodermal lineages during mid-to-late embryogenesis, with postembryonic expression detected in hypodermal seam cells, cells of the P lineage which will give rise to ventral cord neurons, and cells of the somatic gonad, the vulva, and the intestine. | Paper_evidence | WBPaper00003752 | |||||
| WBPaper00004192 | |||||||||
| WBPaper00005298 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables protein serine/threonine kinase activity. Involved in nematode larval development; positive regulation of cell cycle process; and reproductive process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Expressed in gonad; intestine; neurons; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00046296 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Feb 2015 00:00:00 | ||||||||
| Potential_model (24) | |||||||||
| Models_disease_in_annotation | WBDOannot00000346 | ||||||||
| Molecular_info | Corresponding_CDS | F18H3.5 | |||||||
| Corresponding_CDS_history | F18H3.5b:wp61 | ||||||||
| F18H3.5b:wp271 | |||||||||
| Corresponding_transcript | F18H3.5.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature | WBsf654531 | ||||||||
| WBsf671198 | |||||||||
| WBsf1007631 | |||||||||
| WBsf1024243 | |||||||||
| WBsf238141 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr1156 | ||||||||
| Expr1017984 | |||||||||
| Expr1030223 | |||||||||
| Expr1148945 | |||||||||
| Expr2009811 | |||||||||
| Expr2028052 | |||||||||
| Drives_construct | WBCnstr00010112 | ||||||||
| WBCnstr00016185 | |||||||||
| WBCnstr00020118 | |||||||||
| WBCnstr00020130 | |||||||||
| WBCnstr00021180 | |||||||||
| WBCnstr00037565 | |||||||||
| Construct_product | WBCnstr00010112 | ||||||||
| WBCnstr00016185 | |||||||||
| WBCnstr00020118 | |||||||||
| WBCnstr00020130 | |||||||||
| WBCnstr00037565 | |||||||||
| Regulate_expr_cluster | WBPaper00040426:CYD-1_CDK-4_downregulated | ||||||||
| WBPaper00040426:CYD-1_CDK-4_upregulated | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (137) | |||||||||
| Interaction (61) | |||||||||
| Map_info | Map | X | Position | 12.6771 | Error | 0.006799 | |||
| Positive | Positive_clone | F18H3 | Person_evidence | WBPerson346 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| H06A10 | Person_evidence | WBPerson346 | |||||||
| Mapping_data | Multi_point | 4138 | |||||||
| 4196 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (36) | |||||||||
| Remark | The deletion allele was isolated in a PCR-based screen following the method of Barstead and Moulder. The deletion break points have been identified by sequence. We have rescued the cdk-4(gv3) mutant using a wild type copy of the cdk-4 cDNA expressed under the control of cdk-4 ~3 kb of 5' flanking sequences. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
