WormBase Tree Display for Gene: WBGene00000367
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| WBGene00000367 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cca-1 | Person_evidence | WBPerson604 | |||||
| Sequence_name | C54D2.5 | ||||||||
| Molecular_name (17) | |||||||||
| Other_name | CELE_C54D2.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | cca-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cca | ||||||||
| Allele (488) | |||||||||
| Strain | WBStrain00035024 | ||||||||
| WBStrain00035026 | |||||||||
| WBStrain00002849 | |||||||||
| WBStrain00022216 | |||||||||
| WBStrain00033162 | |||||||||
| WBStrain00035498 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00001187 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00003558 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006742 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006809 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cca-1 encodes a calcium channel alpha subunit that is homologous to vertebrate T-type calcium channel alpha 1 subunits; CCA-1 is required for regulation of pharyngeal pumping, specifically for the efficient initiation of action potentials in the pharynx in response to excitatory inputs; a CCA-1::GFP fusion protein is expressed strongly in pharyngeal muscle as well as in many neurons, including particular subsets of neurons in the head, pharynx, ventral nerve cord, and anal ganglia. | Paper_evidence | WBPaper00025209 | |||||
| WBPaper00025210 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson480 | |||||||||
| Date_last_updated | 18 Oct 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable low voltage-gated calcium channel activity. Involved in membrane depolarization; positive regulation of action potential; and regulation of pharyngeal pumping. Predicted to be located in neuron projection. Predicted to be part of voltage-gated sodium channel complex. Expressed in several structures, including alimentary muscle; distal tip cell; pharyngeal neurons; serotonergic neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including cerebellar ataxia type 42; childhood absence epilepsy; and primary hyperaldosteronism. Is an ortholog of human CACNA1I (calcium voltage-gated channel subunit alpha1 I). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:446 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1395) | ||||
| DOID:1825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1395) | ||||||
| DOID:0111742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1394) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1396) | ||||||
| Molecular_info | Corresponding_CDS | C54D2.5a | |||||||
| C54D2.5c | |||||||||
| C54D2.5d | |||||||||
| C54D2.5e | |||||||||
| C54D2.5g | |||||||||
| Corresponding_CDS_history | C54D2.5b:wp170 | ||||||||
| C54D2.5f:wp245 | |||||||||
| Corresponding_transcript | C54D2.5a.1 | ||||||||
| C54D2.5a.2 | |||||||||
| C54D2.5a.3 | |||||||||
| C54D2.5c.1 | |||||||||
| C54D2.5d.1 | |||||||||
| C54D2.5e.1 | |||||||||
| C54D2.5g.1 | |||||||||
| Other_sequence (29) | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00012391 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00043146 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00003371 | ||||||||
| WBCnstr00004844 | |||||||||
| WBCnstr00004846 | |||||||||
| WBCnstr00011900 | |||||||||
| Microarray_results (41) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (22) | |||||||||
| Map_info | Map | X | Position | -1.05786 | Error | 0.020226 | |||
| Positive | Positive_clone | C54D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4178 | |||||||
| 4653 | |||||||||
| 4766 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (38) | |||||||||
| Remark | AF368920 contains the experimentally derived cDNA sequence. It differs in several regards from the sequence predicted from analysis of cosmid C54D2 (product 5). | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
