WormBase Tree Display for Gene: WBGene00000367
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WBGene00000367 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cca | ||||||
Allele (488) | |||||||
Strain | WBStrain00035024 | ||||||
WBStrain00035026 | |||||||
WBStrain00002849 | |||||||
WBStrain00022216 | |||||||
WBStrain00033162 | |||||||
WBStrain00035498 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (30) | |||||||
Ortholog (47) | |||||||
Paralog | WBGene00001187 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00003558 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006742 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006809 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | cca-1 encodes a calcium channel alpha subunit that is homologous to vertebrate T-type calcium channel alpha 1 subunits; CCA-1 is required for regulation of pharyngeal pumping, specifically for the efficient initiation of action potentials in the pharynx in response to excitatory inputs; a CCA-1::GFP fusion protein is expressed strongly in pharyngeal muscle as well as in many neurons, including particular subsets of neurons in the head, pharynx, ventral nerve cord, and anal ganglia. | Paper_evidence | WBPaper00025209 | |||
WBPaper00025210 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson480 | |||||||
Date_last_updated | 18 Oct 2006 00:00:00 | ||||||
Automated_description | Predicted to enable low voltage-gated calcium channel activity. Involved in membrane depolarization; positive regulation of action potential; and regulation of pharyngeal pumping. Predicted to be located in neuron projection. Predicted to be part of voltage-gated sodium channel complex. Expressed in several structures, including alimentary muscle; distal tip cell; pharyngeal neurons; serotonergic neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including cerebellar ataxia type 42; childhood absence epilepsy; and primary hyperaldosteronism. Is an ortholog of human CACNA1I (calcium voltage-gated channel subunit alpha1 I). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:446 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1395) | ||
DOID:1825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1395) | ||||
DOID:0111742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1394) | ||||
DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1396) | ||||
Molecular_info | Corresponding_CDS | C54D2.5a | |||||
C54D2.5c | |||||||
C54D2.5d | |||||||
C54D2.5e | |||||||
C54D2.5g | |||||||
Corresponding_CDS_history | C54D2.5b:wp170 | ||||||
C54D2.5f:wp245 | |||||||
Corresponding_transcript | C54D2.5a.1 | ||||||
C54D2.5a.2 | |||||||
C54D2.5a.3 | |||||||
C54D2.5c.1 | |||||||
C54D2.5d.1 | |||||||
C54D2.5e.1 | |||||||
C54D2.5g.1 | |||||||
Other_sequence (29) | |||||||
Associated_feature (24) | |||||||
Experimental_info | RNAi_result | WBRNAi00012391 | Inferred_automatically | RNAi_primary | |||
WBRNAi00043146 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (12) | |||||||
Drives_construct | WBCnstr00003371 | ||||||
WBCnstr00004844 | |||||||
WBCnstr00004846 | |||||||
WBCnstr00011900 | |||||||
Microarray_results (41) | |||||||
Expression_cluster (141) | |||||||
Interaction (22) | |||||||
Map_info | Map | X | Position | -1.05786 | Error | 0.020226 | |
Positive | Positive_clone | C54D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4178 | |||||
4653 | |||||||
4766 | |||||||
Pseudo_map_position | |||||||
Reference (38) | |||||||
Remark | AF368920 contains the experimentally derived cDNA sequence. It differs in several regards from the sequence predicted from analysis of cosmid C54D2 (product 5). | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |