WormBase Tree Display for Gene: WBGene00000298
expand all nodes | collapse all nodes | view schema
| WBGene00000298 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cat-4 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F32G8.6 | ||||||||
| Molecular_name | F32G8.6 | ||||||||
| F32G8.6.1 | |||||||||
| CE05795 | |||||||||
| Other_name | gtpch-1 | Paper_evidence | WBPaper00005354 | ||||||
| CELE_F32G8.6 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | cat-4 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cat | ||||||||
| Reference_allele | WBVar00143773 | ||||||||
| Allele (28) | |||||||||
| Legacy_information | e1141 : dopamine reduced > 90%. ES1 ME2 NA1. | ||||||||
| [Leon Avery] Serotonin is reduced or absent (CGC#1105). | |||||||||
| See also e1141 | |||||||||
| [C.elegansII] e1141 : dopamine reduced > 90%, serotonin reduced orabsent; poor male turning behavior; enhanced foraging behavior, suppressed by serotonin agonists; serotonin immunoreactivity restored by exogenous serotonin or 5-hydroxytryptophan;cuticle defective, hypersensitive to SDS, levamisole,hypochlorite.. ES1 ME2 NA1. [Sulston et al. 1975; Loer and Kenyon 1993; DA; KP; LC] | |||||||||
| Strain | WBStrain00024111 | ||||||||
| WBStrain00024121 | |||||||||
| WBStrain00027351 | |||||||||
| WBStrain00004253 | |||||||||
| WBStrain00004816 | |||||||||
| WBStrain00024116 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (39) | |||||||||
| Structured_description | Automated_description | Enables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; dopaminergic neurons; hyp7 syncytium; intestinal cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; and movement disease (multiple). Is an ortholog of human GCH1 (GTP cyclohydrolase 1). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (11) | ||||||||
| Molecular_info | Corresponding_CDS | F32G8.6 | |||||||
| Corresponding_transcript | F32G8.6.1 | ||||||||
| Other_sequence (413) | |||||||||
| Associated_feature | WBsf047518 | ||||||||
| WBsf047519 | |||||||||
| WBsf047520 | |||||||||
| WBsf1001139 | |||||||||
| WBsf1020318 | |||||||||
| WBsf232395 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00031695 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00115602 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014232 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115714 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00046157 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115603 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115701 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4817 | ||||||||
| Expr12165 | |||||||||
| Expr1027591 | |||||||||
| Expr1150045 | |||||||||
| Expr2009728 | |||||||||
| Expr2027967 | |||||||||
| Drives_construct | WBCnstr00012257 | ||||||||
| WBCnstr00015879 | |||||||||
| WBCnstr00017075 | |||||||||
| WBCnstr00020335 | |||||||||
| WBCnstr00037596 | |||||||||
| Construct_product | WBCnstr00012257 | ||||||||
| WBCnstr00037596 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (261) | |||||||||
| Interaction (175) | |||||||||
| Map_info | Map | V | Position | 2.59941 | Error | 0.001738 | |||
| Positive | Positive_clone | F32G8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 151 | |||||||
| 1529 | |||||||||
| 2269 | |||||||||
| Pos_neg_data | 6765 | ||||||||
| 6766 | |||||||||
| 6767 | |||||||||
| 6769 | |||||||||
| 6771 | |||||||||
| Reference (94) | |||||||||
| Remark | Interacting_genes '[Leon Avery] unc-31: cat-4 enhances the Egl defect of unc-31 mutants, especially at 15C. | ||||||||
| Method | Gene |
