WormBase Tree Display for Gene: WBGene00000298

WBGene00000298 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 1
    Name: CGC_name: cat-4 Person_evidence: WBPerson261
      Sequence_name: F32G8.6
      Molecular_name: F32G8.6
        F32G8.6.1
        CE05795
      Other_name: gtpch-1 Paper_evidence: WBPaper00005354
        CELE_F32G8.6 Accession_evidence: NDB BX284605
      Public_name: cat-4
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cat
    Reference_allele: WBVar00143773
    Allele (28)
    Legacy_information: e1141 : dopamine reduced > 90%. ES1 ME2 NA1.
      [Leon Avery] Serotonin is reduced or absent (CGC#1105).
      See also e1141
      [C.elegansII] e1141 : dopamine reduced > 90%, serotonin reduced orabsent; poor male turning behavior; enhanced foraging behavior, suppressed by serotonin agonists; serotonin immunoreactivity restored by exogenous serotonin or 5-hydroxytryptophan;cuticle defective, hypersensitive to SDS, levamisole,hypochlorite.. ES1 ME2 NA1. [Sulston et al. 1975; Loer and Kenyon 1993; DA; KP; LC]
    Strain: WBStrain00024111
      WBStrain00024121
      WBStrain00027351
      WBStrain00004253
      WBStrain00004816
      WBStrain00024116
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (39)
    Structured_description: Automated_description: Enables GTP cyclohydrolase I activity. Involved in dopamine biosynthetic process from tyrosine; melanin biosynthetic process; and tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; dopaminergic neurons; hyp7 syncytium; intestinal cell; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; and movement disease (multiple). Is an ortholog of human GCH1 (GTP cyclohydrolase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: F32G8.6
    Corresponding_transcript: F32G8.6.1
    Other_sequence (413)
    Associated_feature: WBsf047518
      WBsf047519
      WBsf047520
      WBsf1001139
      WBsf1020318
      WBsf232395
  Experimental_info: RNAi_result: WBRNAi00031695 Inferred_automatically: RNAi_primary
      WBRNAi00115602 Inferred_automatically: RNAi_primary
      WBRNAi00014232 Inferred_automatically: RNAi_primary
      WBRNAi00115714 Inferred_automatically: RNAi_primary
      WBRNAi00046157 Inferred_automatically: RNAi_primary
      WBRNAi00115603 Inferred_automatically: RNAi_primary
      WBRNAi00115701 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4817
      Expr12165
      Expr1027591
      Expr1150045
      Expr2009728
      Expr2027967
    Drives_construct: WBCnstr00012257
      WBCnstr00015879
      WBCnstr00017075
      WBCnstr00020335
      WBCnstr00037596
    Construct_product: WBCnstr00012257
      WBCnstr00037596
    Microarray_results (19)
    Expression_cluster (261)
    Interaction: WBInteraction000000678
      WBInteraction000028432
      WBInteraction000030014
      WBInteraction000030015
      WBInteraction000030016
      WBInteraction000033858
      WBInteraction000035355
      WBInteraction000038974
      WBInteraction000043551
      WBInteraction000046423
      WBInteraction000046424
      WBInteraction000136445
      WBInteraction000138287
      WBInteraction000141487
      WBInteraction000141697
      WBInteraction000143461
      WBInteraction000143621
      WBInteraction000144521
      WBInteraction000145380
      WBInteraction000147725
      WBInteraction000151192
      WBInteraction000151660
      WBInteraction000152532
      WBInteraction000162773
      WBInteraction000163493
      WBInteraction000165752
      WBInteraction000175081
      WBInteraction000176413
      WBInteraction000179548
      WBInteraction000185017
      WBInteraction000186380
      WBInteraction000187406
      WBInteraction000188194
      WBInteraction000199465
      WBInteraction000201984
      WBInteraction000205755
      WBInteraction000207812
      WBInteraction000215425
      WBInteraction000217764
      WBInteraction000220364
      WBInteraction000222108
      WBInteraction000224228
      WBInteraction000229484
      WBInteraction000229832
      WBInteraction000232557
      WBInteraction000237439
      WBInteraction000242061
      WBInteraction000251996
      WBInteraction000256355
      WBInteraction000259661
      WBInteraction000260039
      WBInteraction000260937
      WBInteraction000267023
      WBInteraction000268500
      WBInteraction000272973
      WBInteraction000275920
      WBInteraction000275990
      WBInteraction000281464
      WBInteraction000283667
      WBInteraction000283830
      WBInteraction000285466
      WBInteraction000289411
      WBInteraction000289603
      WBInteraction000295031
      WBInteraction000295093
      WBInteraction000302206
      WBInteraction000303092
      WBInteraction000303131
      WBInteraction000306941
      WBInteraction000309792
      WBInteraction000312746
      WBInteraction000313360
      WBInteraction000314955
      WBInteraction000315487
      WBInteraction000315899
      WBInteraction000316079
      WBInteraction000323332
      WBInteraction000325988
      WBInteraction000328529
      WBInteraction000338432
      WBInteraction000338433
      WBInteraction000348081
      WBInteraction000348856
      WBInteraction000349160
      WBInteraction000349540
      WBInteraction000350734
      WBInteraction000352444
      WBInteraction000355347
      WBInteraction000357080
      WBInteraction000358575
      WBInteraction000358588
      WBInteraction000361316
      WBInteraction000369792
      WBInteraction000371287
      WBInteraction000372713
      WBInteraction000375831
      WBInteraction000375847
      WBInteraction000377688
      WBInteraction000378595
      WBInteraction000379196
      WBInteraction000380495
      WBInteraction000384089
      WBInteraction000386928
      WBInteraction000390173
      WBInteraction000396446
      WBInteraction000396597
      WBInteraction000398733
      WBInteraction000399574
      WBInteraction000401585
      WBInteraction000407588
      WBInteraction000409368
      WBInteraction000410646
      WBInteraction000412089
      WBInteraction000412881
      WBInteraction000422250
      WBInteraction000422642
      WBInteraction000425060
      WBInteraction000425209
      WBInteraction000434426
      WBInteraction000434564
      WBInteraction000439068
      WBInteraction000442220
      WBInteraction000442296
      WBInteraction000443180
      WBInteraction000443612
      WBInteraction000444277
      WBInteraction000444507
      WBInteraction000446615
      WBInteraction000447099
      WBInteraction000452835
      WBInteraction000454343
      WBInteraction000454797
      WBInteraction000457520
      WBInteraction000457717
      WBInteraction000457862
      WBInteraction000458018
      WBInteraction000458212
      WBInteraction000466756
      WBInteraction000468274
      WBInteraction000471725
      WBInteraction000500584
      WBInteraction000501785
      WBInteraction000502215
      WBInteraction000503944
      WBInteraction000511480
      WBInteraction000511481
      WBInteraction000511482
      WBInteraction000511483
      WBInteraction000511484
      WBInteraction000511485
      WBInteraction000511486
      WBInteraction000511487
      WBInteraction000511490
      WBInteraction000511491
      WBInteraction000511492
      WBInteraction000511493
      WBInteraction000511495
      WBInteraction000520372
      WBInteraction000524294
      WBInteraction000541881
      WBInteraction000542152
      WBInteraction000544400
      WBInteraction000544428
      WBInteraction000545976
      WBInteraction000546040
      WBInteraction000546085
      WBInteraction000546090
      WBInteraction000547969
      WBInteraction000547970
      WBInteraction000555810
      WBInteraction000556666
      WBInteraction000556670
      WBInteraction000556897
      WBInteraction000560598
      WBInteraction000569795
  Map_info: Map: V Position: 2.59941 Error: 0.001738
    Positive: Positive_clone: F32G8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 151
        1529
        2269
      Pos_neg_data: 6765
        6766
        6767
        6769
        6771
  Reference (94)
  Remark: Interacting_genes '[Leon Avery] unc-31: cat-4 enhances the Egl defect of unc-31 mutants, especially at 15C.
  Method: Gene