WormBase Tree Display for Gene: WBGene00000266
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| WBGene00000266 | SMap | S_parent | Sequence | C53B4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | bre-1 | Person_evidence | WBPerson26 | |||||
| Sequence_name | C53B4.7 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | gmd-1 | Paper_evidence | WBPaper00028852 | ||||||
| Person_evidence | WBPerson2099 | ||||||||
| CELE_C53B4.7 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | bre-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 15 Dec 2006 14:54:17 | WBPerson1847 | Event | Acquires_merge | WBGene00008276 | ||||
| Name_change | Other_name | gmd-1 | |||||||
| Acquires_merge | WBGene00008276 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | bre | ||||||||
| Allele (43) | |||||||||
| Legacy_information | [Marroquin LD, Aroian RV ] Weakly resistant to Bt toxin, Cry5B | ||||||||
| Strain | WBStrain00001304 | ||||||||
| WBStrain00008570 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (45) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | bre-1 encodes one of two C. elegans GDP-mannose 4, 6-dehydratases; BRE-1 exhibits GDP-mannose dehydratase activity when expressed in vitro and thus, is predicted to function in vivo in the first step of the biosynthetic pathway that synthesizes GDP-fucose from GDP-mannose; bre-1 is required for toxicity to Cry5B, a Bacillus thurigensis delta-endotoxin, as mutant animals are defective for production of fucosylated glycolipids that act as a receptor for Cry5B; bre-1 mutant animals are also resistant to a fungal toxin Coprinopsis cinerea CGL2; bre-1 mutant animals demonstrate lack of fucosylated N- and O-glycans; bre-1 is expressed in larval and adult stages. | Paper_evidence | WBPaper00004264 | |||||
| WBPaper00027362 | |||||||||
| WBPaper00028852 | |||||||||
| WBPaper00035585 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 Apr 2010 00:00:00 | ||||||||
| Automated_description | Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and response to toxic substance. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Human ortholog(s) of this gene implicated in open-angle glaucoma. Is an ortholog of human GMDS (GDP-mannose 4,6-dehydratase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1067 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4369) | ||||
| Molecular_info | Corresponding_CDS | C53B4.7a | |||||||
| C53B4.7b | |||||||||
| C53B4.7c | |||||||||
| C53B4.7d | |||||||||
| C53B4.7e | |||||||||
| Corresponding_CDS_history | C53B4.7:wp47 | ||||||||
| Corresponding_transcript | C53B4.7a.1 | ||||||||
| C53B4.7b.1 | |||||||||
| C53B4.7c.1 | |||||||||
| C53B4.7d.1 | |||||||||
| C53B4.7e.1 | |||||||||
| Other_sequence (75) | |||||||||
| Associated_feature | WBsf646202 | ||||||||
| WBsf646203 | |||||||||
| WBsf646204 | |||||||||
| WBsf646205 | |||||||||
| WBsf659838 | |||||||||
| WBsf997329 | |||||||||
| WBsf997330 | |||||||||
| WBsf1017907 | |||||||||
| WBsf228775 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002197 | ||||||||
| WBCnstr00037617 | |||||||||
| Construct_product | WBCnstr00013991 | ||||||||
| WBCnstr00037617 | |||||||||
| Microarray_results (44) | |||||||||
| Expression_cluster (230) | |||||||||
| Interaction | WBInteraction000038986 | ||||||||
| WBInteraction000547585 | |||||||||
| WBInteraction000551697 | |||||||||
| WBInteraction000574221 | |||||||||
| WBInteraction000574582 | |||||||||
| WBInteraction000578560 | |||||||||
| WBInteraction000582903 | |||||||||
| WBInteraction000584992 | |||||||||
| Map_info | Map | IV | Position | 4.00022 | Error | 0.000243 | |||
| Positive | Positive_clone | C53B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 7118 | |||||||
| Reference (24) | |||||||||
| Remark | Data extracted from Marroquin et al. (2000) | ||||||||
| Method | Gene |
