WormBase Tree Display for Gene: WBGene00000266
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WBGene00000266 | SMap | S_parent | Sequence | C53B4 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | bre-1 | Person_evidence | WBPerson26 | |||
Sequence_name | C53B4.7 | ||||||
Molecular_name (15) | |||||||
Other_name | gmd-1 | Paper_evidence | WBPaper00028852 | ||||
Person_evidence | WBPerson2099 | ||||||
CELE_C53B4.7 | Accession_evidence | NDB | BX284604 | ||||
Public_name | bre-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Acquires_merge | WBGene00008276 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | bre | ||||||
Allele (43) | |||||||
Legacy_information | [Marroquin LD, Aroian RV ] Weakly resistant to Bt toxin, Cry5B | ||||||
Strain | WBStrain00001304 | ||||||
WBStrain00008570 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (23) | |||||||
Ortholog (45) | |||||||
Paralog (13) | |||||||
Structured_description | Concise_description | bre-1 encodes one of two C. elegans GDP-mannose 4, 6-dehydratases; BRE-1 exhibits GDP-mannose dehydratase activity when expressed in vitro and thus, is predicted to function in vivo in the first step of the biosynthetic pathway that synthesizes GDP-fucose from GDP-mannose; bre-1 is required for toxicity to Cry5B, a Bacillus thurigensis delta-endotoxin, as mutant animals are defective for production of fucosylated glycolipids that act as a receptor for Cry5B; bre-1 mutant animals are also resistant to a fungal toxin Coprinopsis cinerea CGL2; bre-1 mutant animals demonstrate lack of fucosylated N- and O-glycans; bre-1 is expressed in larval and adult stages. | Paper_evidence | WBPaper00004264 | |||
WBPaper00027362 | |||||||
WBPaper00028852 | |||||||
WBPaper00035585 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 09 Apr 2010 00:00:00 | ||||||
Automated_description | Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and response to toxic substance. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Human ortholog(s) of this gene implicated in open-angle glaucoma. Is an ortholog of human GMDS (GDP-mannose 4,6-dehydratase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:1067 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4369) | ||
Molecular_info | Corresponding_CDS | C53B4.7a | |||||
C53B4.7b | |||||||
C53B4.7c | |||||||
C53B4.7d | |||||||
C53B4.7e | |||||||
Corresponding_CDS_history | C53B4.7:wp47 | ||||||
Corresponding_transcript | C53B4.7a.1 | ||||||
C53B4.7b.1 | |||||||
C53B4.7c.1 | |||||||
C53B4.7d.1 | |||||||
C53B4.7e.1 | |||||||
Other_sequence (75) | |||||||
Associated_feature | WBsf646202 | ||||||
WBsf646203 | |||||||
WBsf646204 | |||||||
WBsf646205 | |||||||
WBsf659838 | |||||||
WBsf997329 | |||||||
WBsf997330 | |||||||
WBsf1017907 | |||||||
WBsf228775 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00002197 | ||||||
WBCnstr00037617 | |||||||
Construct_product | WBCnstr00013991 | ||||||
WBCnstr00037617 | |||||||
Microarray_results (44) | |||||||
Expression_cluster (230) | |||||||
Interaction | WBInteraction000038986 | ||||||
WBInteraction000547585 | |||||||
WBInteraction000551697 | |||||||
WBInteraction000574221 | |||||||
WBInteraction000574582 | |||||||
WBInteraction000578560 | |||||||
WBInteraction000582903 | |||||||
WBInteraction000584992 | |||||||
Map_info | Map | IV | Position | 4.00022 | Error | 0.000243 | |
Positive | Positive_clone | C53B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 7118 | |||||
Reference (24) | |||||||
Remark | Data extracted from Marroquin et al. (2000) | ||||||
Method | Gene |