WormBase Tree Display for Gene: WBGene00000205
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| WBGene00000205 | Evidence | Paper_evidence | WBPaper00005843 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | M01B12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | arx-7 | Person_evidence | WBPerson633 | |||||
| Sequence_name | M01B12.3 | ||||||||
| Molecular_name | M01B12.3 | ||||||||
| M01B12.3.1 | |||||||||
| CE18061 | |||||||||
| Other_name | M01B12.d | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_M01B12.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | arx-7 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | arx | ||||||||
| Allele (16) | |||||||||
| Strain | WBStrain00036045 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00016729 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | arx-7 also called as p16Arc encodes a subunit of the actin related protein of the conserved Arp2/3 complex, with 60% amino acid similarity with the homologous genes from human (OMIM: 604227); arx-7 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure during morphogenesis; Arp2/3 depletion results in partial shrinking of the Ea/p apical surfaces and incomplete Ea/p cell internalization; WSP-1 activates Arp2/3 complex and their function in ventral enclosure is cell autonomous; Arp2/3 regulates some Apical Junction components in embryos and adults; Arp2/3 is required during intestinal morphogenesis for regulation of intestinal lumen width in embryos and apical F-actin accumulation during larval and adult growth. Mutations in arx-7 cause PDE axon guidance defects; arx-7 mutants affect PQR growth cone morphology and filopodia formation; arx-7 acts cell-autonomously in PQR filopodia regulation. | Paper_evidence | WBPaper00005843 | |||||
| WBPaper00035279 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 10 Aug 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; epithelial cell migration; and morphogenesis of embryonic epithelium. Located in cytoplasm. Expressed in anchor cell; hypodermis; and linker cell. Human ortholog(s) of this gene implicated in lung squamous cell carcinoma. Is an ortholog of human ARPC5 (actin related protein 2/3 complex subunit 5) and ARPC5L (actin related protein 2/3 complex subunit 5 like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:708) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:708) | ||||||
| DOID:3907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:708) | ||||||
| Molecular_info | Corresponding_CDS | M01B12.3 | |||||||
| Corresponding_transcript | M01B12.3.1 | ||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf649005 | ||||||||
| WBsf664009 | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr2465 | ||||||||
| Expr11144 | |||||||||
| Expr14542 | |||||||||
| Expr1013184 | |||||||||
| Expr1030124 | |||||||||
| Expr1154418 | |||||||||
| Expr2009440 | |||||||||
| Expr2027677 | |||||||||
| Drives_construct | WBCnstr00018184 | ||||||||
| WBCnstr00041081 | |||||||||
| Construct_product | WBCnstr00005815 | ||||||||
| WBCnstr00041081 | |||||||||
| Antibody | WBAntibody00000619 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (83) | |||||||||
| Interaction (45) | |||||||||
| Map_info | Map | I | Position | -4.4948 | Error | 0.003832 | |||
| Positive | Positive_clone | M01B12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5132 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005843 | ||||||||
| WBPaper00025147 | |||||||||
| WBPaper00032282 | |||||||||
| WBPaper00035279 | |||||||||
| WBPaper00037146 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041549 | |||||||||
| WBPaper00054817 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056095 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
