WormBase Tree Display for Gene: WBGene00000197
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| WBGene00000197 | SMap | S_parent | Sequence | F28H1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | aars-2 | Person_evidence | WBPerson36 | |||||
| WBPerson10953 | |||||||||
| Sequence_name | F28H1.3 | ||||||||
| Molecular_name | F28H1.3 | ||||||||
| F28H1.3.1 | |||||||||
| CE09768 | |||||||||
| F28H1.3.2 | |||||||||
| Other_name | ars-2 | ||||||||
| let-366 | Person_evidence | WBPerson533 | |||||||
| CELE_F28H1.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | aars-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 29 Jan 2010 14:16:16 | WBPerson2970 | Name_change | CGC_name | aars-2 | ||||
| Other_name | ars-2 | ||||||||
| 3 | 03 Mar 2015 12:31:28 | WBPerson2970 | Event | Acquires_merge | WBGene00002586 | ||||
| Name_change | Other_name | let-366 | |||||||
| 4 | 05 Mar 2015 17:13:53 | WBPerson2970 | Event | Resurrected | |||||
| Acquires_merge | WBGene00002586 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aars | ||||||||
| Allele (49) | |||||||||
| Legacy_information | [C.elegansII] h112 : mid-larval lethal. OA6: h265 (lethal), etc. [Howell and Rose 1990; KR] | ||||||||
| Strain | WBStrain00023699 | ||||||||
| WBStrain00023808 | |||||||||
| RNASeq_FPKM (72) | |||||||||
| GO_annotation (28) | |||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00000196 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; AARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; AARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development. | Paper_evidence | WBPaper00004402 | |||||
| WBPaper00004424 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in alanyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; and trichothiodystrophy. Is an ortholog of human AARS1 (alanyl-tRNA synthetase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110177 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20) | ||||
| DOID:10579 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20) | ||||||
| DOID:0080451 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20) | ||||||
| DOID:0111866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20) | ||||||
| Molecular_info | Corresponding_CDS | F28H1.3 | |||||||
| Corresponding_transcript | F28H1.3.1 | ||||||||
| F28H1.3.2 | |||||||||
| Other_sequence (89) | |||||||||
| Associated_feature | WBsf643172 | ||||||||
| WBsf656135 | |||||||||
| WBsf983293 | |||||||||
| WBsf983294 | |||||||||
| WBsf217463 | |||||||||
| WBsf217464 | |||||||||
| WBsf217465 | |||||||||
| WBsf217466 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr2064 | ||||||||
| Expr1014484 | |||||||||
| Expr1030116 | |||||||||
| Expr1149771 | |||||||||
| Expr2009063 | |||||||||
| Expr2027299 | |||||||||
| Drives_construct | WBCnstr00037994 | ||||||||
| Construct_product | WBCnstr00037994 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (142) | |||||||||
| Interaction (242) | |||||||||
| Map_info | Map | I | Position | -1.89759 | Error | 0.003406 | |||
| Positive | Positive_clone | F28H1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | 2_point | 2533 | |||||||
| Multi_point | 1019 | ||||||||
| Pos_neg_data | 2567 | ||||||||
| 2679 | |||||||||
| 3763 | |||||||||
| 4109 | |||||||||
| 6252 | |||||||||
| 4098 | |||||||||
| 4133 | |||||||||
| 6153 | |||||||||
| 6308 | |||||||||
| 6325 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00000975 | ||||||||
| WBPaper00001339 | |||||||||
| WBPaper00003985 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040589 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | dl1 : probably cytoplasmic | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| [150305 mt3] Gene Resurrected via id_ressurect.pl Additional comments: | |||||||||
| Method | Gene |
