WormBase Tree Display for Gene: WBGene00000197

WBGene00000197 SMap: S_parent: Sequence: F28H1
  Identity: Version: 4
    Name: CGC_name: aars-2 Person_evidence: WBPerson36
            WBPerson10953
      Sequence_name: F28H1.3
      Molecular_name: F28H1.3
        F28H1.3.1
        CE09768
        F28H1.3.2
      Other_name: ars-2
        let-366 Person_evidence: WBPerson533
        CELE_F28H1.3 Accession_evidence: NDB BX284601
      Public_name: aars-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Jan 2010 14:16:16 WBPerson2970 Name_change: CGC_name: aars-2
                Other_name: ars-2
        3 03 Mar 2015 12:31:28 WBPerson2970 Event: Acquires_merge: WBGene00002586
              Name_change: Other_name: let-366
        4 05 Mar 2015 17:13:53 WBPerson2970 Event: Resurrected
      Acquires_merge: WBGene00002586
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aars
    Allele (49)
    Legacy_information: [C.elegansII] h112 : mid-larval lethal. OA6: h265 (lethal), etc. [Howell and Rose 1990; KR]
    Strain: WBStrain00023699
      WBStrain00023808
    RNASeq_FPKM (72)
    GO_annotation (28)
    Ortholog: WBGene00157610 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00161537 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00062366 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00033089 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00233939 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10235 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g10237 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3926 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g14810 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g6989 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g1946 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8415 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4461 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g2873 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g10723 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g21265 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g2580 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g26522 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g27164 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g16397 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_02278.g17020 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_05157.g19397 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-aars-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold627.g6673 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00212.g7153 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_08256 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_002252 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06245 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g8936 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10154700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g625 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00133967 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00238394 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00113192 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00256933 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00289603 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000005862 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0027094 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0028962 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-030131-3663 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:20 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2384560 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1304832 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00000196 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: aars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; AARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; AARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development. Paper_evidence: WBPaper00004402
            WBPaper00004424
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in alanyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; and trichothiodystrophy. Is an ortholog of human AARS1 (alanyl-tRNA synthetase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110177 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20)
      DOID:10579 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20)
      DOID:0080451 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20)
      DOID:0111866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20)
  Molecular_info: Corresponding_CDS: F28H1.3
    Corresponding_transcript: F28H1.3.1
      F28H1.3.2
    Other_sequence (89)
    Associated_feature: WBsf643172
      WBsf656135
      WBsf983293
      WBsf983294
      WBsf217463
      WBsf217464
      WBsf217465
      WBsf217466
  Experimental_info: RNAi_result (13)
    Expr_pattern: Expr2064
      Expr1014484
      Expr1030116
      Expr1149771
      Expr2009063
      Expr2027299
    Drives_construct: WBCnstr00037994
    Construct_product: WBCnstr00037994
    Microarray_results (24)
    Expression_cluster (142)
    Interaction (242)
  Map_info: Map: I Position: -1.89759 Error: 0.003406
    Positive: Positive_clone: F28H1 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 2533
      Multi_point: 1019
      Pos_neg_data: 2567
        2679
        3763
        4109
        6252
        4098
        4133
        6153
        6308
        6325
    Pseudo_map_position
  Reference: WBPaper00000975
    WBPaper00001339
    WBPaper00003985
    WBPaper00038491
    WBPaper00040589
    WBPaper00055090
  Remark: dl1 : probably cytoplasmic
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [150305 mt3] Gene Resurrected via id_ressurect.pl Additional comments:
  Method: Gene