WormBase Tree Display for Gene: WBGene00000156
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| WBGene00000156 | SMap | S_parent | Sequence | K04G2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | apr-1 | Person_evidence | WBPerson419 | |||||
| Sequence_name | K04G2.8 | ||||||||
| Molecular_name | K04G2.8a | ||||||||
| K04G2.8a.1 | |||||||||
| CE06102 | |||||||||
| K04G2.8b | |||||||||
| CE18016 | |||||||||
| K04G2.8c | |||||||||
| CE51809 | |||||||||
| K04G2.8b.1 | |||||||||
| K04G2.8c.1 | |||||||||
| Other_name | APC | Paper_evidence | WBPaper00044307 | ||||||
| CELE_K04G2.8 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | apr-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | apr | ||||||||
| Allele (69) | |||||||||
| Possibly_affected_by | WBVar02153202 | ||||||||
| Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | ||||||||
| Strain | WBStrain00037280 | ||||||||
| WBStrain00000140 | |||||||||
| WBStrain00008585 | |||||||||
| WBStrain00024309 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (77) | |||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 May 2011 00:00:00 | ||||||||
| Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (20) | ||||||||
| Molecular_info | Corresponding_CDS | K04G2.8a | |||||||
| K04G2.8b | |||||||||
| K04G2.8c | |||||||||
| Corresponding_transcript | K04G2.8a.1 | ||||||||
| K04G2.8b.1 | |||||||||
| K04G2.8c.1 | |||||||||
| Other_sequence | AF013950 | ||||||||
| CGC00612_1 | |||||||||
| ACC25655_1 | |||||||||
| EX555243.1 | |||||||||
| CBC06635_1 | |||||||||
| Associated_feature | WBsf656598 | ||||||||
| WBsf218114 | |||||||||
| Experimental_info | RNAi_result (104) | ||||||||
| Expr_pattern | Expr1046 | ||||||||
| Expr4600 | |||||||||
| Expr12119 | |||||||||
| Expr12448 | |||||||||
| Expr15118 | |||||||||
| Expr1028112 | |||||||||
| Expr1030085 | |||||||||
| Expr1153646 | |||||||||
| Expr2009365 | |||||||||
| Expr2027601 | |||||||||
| Drives_construct | WBCnstr00005188 | ||||||||
| WBCnstr00007256 | |||||||||
| WBCnstr00009075 | |||||||||
| WBCnstr00009116 | |||||||||
| WBCnstr00012108 | |||||||||
| WBCnstr00016098 | |||||||||
| WBCnstr00020198 | |||||||||
| WBCnstr00021087 | |||||||||
| WBCnstr00037698 | |||||||||
| Construct_product | WBCnstr00000526 | ||||||||
| WBCnstr00007257 | |||||||||
| WBCnstr00007258 | |||||||||
| WBCnstr00009057 | |||||||||
| WBCnstr00009075 | |||||||||
| WBCnstr00012108 | |||||||||
| WBCnstr00016098 | |||||||||
| WBCnstr00020198 | |||||||||
| WBCnstr00021087 | |||||||||
| WBCnstr00037698 | |||||||||
| Antibody | WBAntibody00000276 | ||||||||
| WBAntibody00000277 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (179) | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | I | Position | 2.43771 | Error | 0.002342 | |||
| Positive | Positive_clone | K04G2 | Person_evidence | WBPerson524 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4159 | |||||||
| 4893 | |||||||||
| 5616 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (108) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Remark (2) | |||||||||
| Method | Gene |
