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WormBase Tree Display for Gene: WBGene00000156

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Name Class

WBGene00000156SMapS_parentSequenceK04G2
IdentityVersion1
NameCGC_nameapr-1Person_evidenceWBPerson419
Sequence_nameK04G2.8
Molecular_nameK04G2.8a
K04G2.8a.1
CE06102
K04G2.8b
CE18016
K04G2.8c
CE51809
K04G2.8b.1
K04G2.8c.1
Other_nameAPCPaper_evidenceWBPaper00044307
CELE_K04G2.8Accession_evidenceNDBBX284601
Public_nameapr-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classapr
Allele (69)
Possibly_affected_byWBVar02153202
Legacy_information[Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01]
StrainWBStrain00037280
WBStrain00000140
WBStrain00008585
WBStrain00024309
RNASeq_FPKM (74)
GO_annotation (77)
OrthologWBGene00070008Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00030061Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00146816Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00150302Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00099225Pristionchus pacificusFrom_analysisOMA
Inparanoid_8
WBGene00122252Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00225075Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g10245Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g7151Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g19096Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g7928Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g4841Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g12319Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g16913Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP32.g8287Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g6146Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g850Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g14192Caenorhabditis tribulationisFrom_analysisWormBase-Compara
CSP40.g16935Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00301.g8801Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-apr-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp5_scaffold_00160.g5962Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_13198Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_000446Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g10596Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g7404Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_10063300Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrI_pilon.g1515Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00237733Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00262578Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00293892Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0026598Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
SonicParanoid
FB:FBgn0015589Drosophila melanogasterFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
ZFIN:ZDB-GENE-031112-7Danio rerioFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
ZFIN:ZDB-GENE-090422-1Danio rerioFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
HGNC:583Homo sapiensFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
HGNC:24036Homo sapiensFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
MGI:88039Mus musculusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
MGI:1346052Mus musculusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
RGD:2123Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
RGD:1308256Rattus norvegicusFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
Panther
Structured_descriptionConcise_descriptionThe apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway.Paper_evidence (12)
Curator_confirmedWBPerson324
WBPerson567
Date_last_updated25 May 2011 00:00:00
Automated_descriptionEnables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (20)
Molecular_infoCorresponding_CDSK04G2.8a
K04G2.8b
K04G2.8c
Corresponding_transcriptK04G2.8a.1
K04G2.8b.1
K04G2.8c.1
Other_sequenceAF013950
CGC00612_1
ACC25655_1
EX555243.1
CBC06635_1
Associated_featureWBsf656598
WBsf218114
Experimental_infoRNAi_result (104)
Expr_patternExpr1046
Expr4600
Expr12119
Expr12448
Expr15118
Expr1028112
Expr1030085
Expr1153646
Expr2009365
Expr2027601
Drives_constructWBCnstr00005188
WBCnstr00007256
WBCnstr00009075
WBCnstr00009116
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
Construct_productWBCnstr00000526
WBCnstr00007257
WBCnstr00007258
WBCnstr00009057
WBCnstr00009075
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
AntibodyWBAntibody00000276
WBAntibody00000277
Microarray_results (25)
Expression_cluster (124)
Interaction (179)
WBProcessWBbiopr:00000073
Map_infoMapIPosition2.43771Error0.002342
PositivePositive_cloneK04G2Person_evidenceWBPerson524
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4159
4893
5616
Pseudo_map_position
Reference (108)
PictureWBPicture0000013084
RemarkData extracted from Rocheleau et al. (1997)
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene