WormBase Tree Display for Gene: WBGene00000156

WBGene00000156 SMap: S_parent: Sequence: K04G2
  Identity: Version: 1
    Name: CGC_name: apr-1 Person_evidence: WBPerson419
      Sequence_name: K04G2.8
      Molecular_name: K04G2.8a
        K04G2.8a.1
        CE06102
        K04G2.8b
        CE18016
        K04G2.8c
        CE51809
        K04G2.8b.1
        K04G2.8c.1
      Other_name: APC Paper_evidence: WBPaper00044307
        CELE_K04G2.8 Accession_evidence: NDB BX284601
      Public_name: apr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: apr
    Allele (69)
    Possibly_affected_by: WBVar02153202
    Legacy_information: [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01]
    Strain: WBStrain00037280
      WBStrain00000140
      WBStrain00008585
      WBStrain00024309
    RNASeq_FPKM (74)
    GO_annotation (77)
    Ortholog (41)
    Structured_description: Concise_description: The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. Paper_evidence (12)
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 25 May 2011 00:00:00
      Automated_description: Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (20)
  Molecular_info: Corresponding_CDS: K04G2.8a
      K04G2.8b
      K04G2.8c
    Corresponding_transcript: K04G2.8a.1
      K04G2.8b.1
      K04G2.8c.1
    Other_sequence: AF013950
      CGC00612_1
      ACC25655_1
      EX555243.1
      CBC06635_1
    Associated_feature: WBsf656598
      WBsf218114
  Experimental_info: RNAi_result (104)
    Expr_pattern: Expr1046
      Expr4600
      Expr12119
      Expr12448
      Expr15118
      Expr1028112
      Expr1030085
      Expr1153646
      Expr2009365
      Expr2027601
    Drives_construct: WBCnstr00005188
      WBCnstr00007256
      WBCnstr00009075
      WBCnstr00009116
      WBCnstr00012108
      WBCnstr00016098
      WBCnstr00020198
      WBCnstr00021087
      WBCnstr00037698
    Construct_product: WBCnstr00000526
      WBCnstr00007257
      WBCnstr00007258
      WBCnstr00009057
      WBCnstr00009075
      WBCnstr00012108
      WBCnstr00016098
      WBCnstr00020198
      WBCnstr00021087
      WBCnstr00037698
    Antibody: WBAntibody00000276
      WBAntibody00000277
    Microarray_results (25)
    Expression_cluster (124)
    Interaction: WBInteraction000000509
      WBInteraction000000575
      WBInteraction000000753
      WBInteraction000000754
      WBInteraction000001726
      WBInteraction000002340
      WBInteraction000002342
      WBInteraction000002585
      WBInteraction000002710
      WBInteraction000002782
      WBInteraction000003344
      WBInteraction000003458
      WBInteraction000006023
      WBInteraction000006227
      WBInteraction000007683
      WBInteraction000008079
      WBInteraction000008080
      WBInteraction000009426
      WBInteraction000009453
      WBInteraction000009517
      WBInteraction000009576
      WBInteraction000009639
      WBInteraction000009662
      WBInteraction000009925
      WBInteraction000028572
      WBInteraction000028907
      WBInteraction000032887
      WBInteraction000033010
      WBInteraction000034034
      WBInteraction000034911
      WBInteraction000035587
      WBInteraction000035961
      WBInteraction000035984
      WBInteraction000036518
      WBInteraction000036519
      WBInteraction000036550
      WBInteraction000036758
      WBInteraction000037406
      WBInteraction000038393
      WBInteraction000039618
      WBInteraction000040188
      WBInteraction000040656
      WBInteraction000040733
      WBInteraction000042660
      WBInteraction000043782
      WBInteraction000044304
      WBInteraction000045863
      WBInteraction000047105
      WBInteraction000047526
      WBInteraction000048030
      WBInteraction000048532
      WBInteraction000048907
      WBInteraction000049265
      WBInteraction000049460
      WBInteraction000049616
      WBInteraction000049943
      WBInteraction000049949
      WBInteraction000052601
      WBInteraction000052602
      WBInteraction000122526
      WBInteraction000126449
      WBInteraction000126689
      WBInteraction000127394
      WBInteraction000127428
      WBInteraction000136069
      WBInteraction000161291
      WBInteraction000161292
      WBInteraction000163171
      WBInteraction000163172
      WBInteraction000165152
      WBInteraction000165478
      WBInteraction000165479
      WBInteraction000165480
      WBInteraction000165481
      WBInteraction000166114
      WBInteraction000166122
      WBInteraction000168467
      WBInteraction000181728
      WBInteraction000197741
      WBInteraction000201561
      WBInteraction000215885
      WBInteraction000220431
      WBInteraction000235718
      WBInteraction000236547
      WBInteraction000245920
      WBInteraction000246352
      WBInteraction000251918
      WBInteraction000259481
      WBInteraction000269634
      WBInteraction000288175
      WBInteraction000299490
      WBInteraction000305218
      WBInteraction000313782
      WBInteraction000335865
      WBInteraction000352929
      WBInteraction000355014
      WBInteraction000356176
      WBInteraction000369335
      WBInteraction000375807
      WBInteraction000389718
      WBInteraction000394134
      WBInteraction000400830
      WBInteraction000411677
      WBInteraction000418748
      WBInteraction000427030
      WBInteraction000430041
      WBInteraction000442259
      WBInteraction000444338
      WBInteraction000500035
      WBInteraction000500036
      WBInteraction000502192
      WBInteraction000502796
      WBInteraction000502797
      WBInteraction000502798
      WBInteraction000502799
      WBInteraction000502801
      WBInteraction000503435
      WBInteraction000505124
      WBInteraction000505125
      WBInteraction000505126
      WBInteraction000505127
      WBInteraction000517877
      WBInteraction000519244
      WBInteraction000519245
      WBInteraction000519250
      WBInteraction000519251
      WBInteraction000519252
      WBInteraction000519253
      WBInteraction000519254
      WBInteraction000519255
      WBInteraction000520246
      WBInteraction000521746
      WBInteraction000521750
      WBInteraction000521853
      WBInteraction000521875
      WBInteraction000521881
      WBInteraction000521882
      WBInteraction000521883
      WBInteraction000521884
      WBInteraction000522263
      WBInteraction000522264
      WBInteraction000522281
      WBInteraction000522308
      WBInteraction000522316
      WBInteraction000523960
      WBInteraction000524831
      WBInteraction000539198
      WBInteraction000541599
      WBInteraction000541603
      WBInteraction000541779
      WBInteraction000541780
      WBInteraction000543618
      WBInteraction000543619
      WBInteraction000543620
      WBInteraction000543621
      WBInteraction000543622
      WBInteraction000543623
      WBInteraction000543624
      WBInteraction000543625
      WBInteraction000543626
      WBInteraction000543627
      WBInteraction000543628
      WBInteraction000543629
      WBInteraction000543630
      WBInteraction000543631
      WBInteraction000547298
      WBInteraction000547711
      WBInteraction000556044
      WBInteraction000556045
      WBInteraction000556046
      WBInteraction000557664
      WBInteraction000557671
      WBInteraction000557678
      WBInteraction000557685
      WBInteraction000557692
      WBInteraction000557699
      WBInteraction000560328
      WBInteraction000578733
      WBInteraction000582080
    WBProcess: WBbiopr:00000073
  Map_info: Map: I Position: 2.43771 Error: 0.002342
    Positive: Positive_clone: K04G2 Person_evidence: WBPerson524
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4159
        4893
        5616
    Pseudo_map_position
  Reference (108)
  Picture: WBPicture0000013084
  Remark: Data extracted from Rocheleau et al. (1997)
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene