WormBase Tree Display for Gene: WBGene00000120
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WBGene00000120 | SMap | S_parent | Sequence | C01F6 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | aly-1 | Person_evidence | WBPerson297 | |||||
WBPerson4981 | |||||||||
Sequence_name | C01F6.5 | ||||||||
Molecular_name | C01F6.5 | ||||||||
C01F6.5.1 | |||||||||
CE02954 | |||||||||
Other_name | ref-1 | Paper_evidence | WBPaper00013477 | ||||||
CELE_C01F6.5 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | aly-1 | ||||||||
DB_info | Database | AceView | gene | 4J873 | |||||
WormQTL | gene | WBGene00000120 | |||||||
WormFlux | gene | WBGene00000120 | |||||||
NDB | locus_tag | CELE_C01F6.5 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000120|UniProtKB=Q17561 | |||||||
family | PTHR19965 | ||||||||
NCBI | gene | 177735 | |||||||
RefSeq | protein | NM_069187.8 | |||||||
TREEFAM | TREEFAM_ID | TF313312 | |||||||
TrEMBL | UniProtAcc | Q17561 | |||||||
UniProt_GCRP | UniProtAcc | Q17561 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 27 Apr 2005 13:40:18 | WBPerson2970 | Name_change | Other_name | ref-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | aly | ||||||||
Allele (20) | |||||||||
Strain | WBStrain00032271 | ||||||||
WBStrain00037646 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00058513 | ||||||||
00058514 | |||||||||
00058515 | |||||||||
00058516 | |||||||||
00106834 | |||||||||
Ortholog (59) | |||||||||
Paralog | WBGene00000121 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000122 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00015329 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | aly-1 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-1 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-2 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-2, ALY-1 and its paralog ALY-2 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; ALY-1 and NXF-2 bind the TRE element in vitro; ALY-1 is also bound competitively by either NXF-2 or TRA-1 in vitro; aly-1(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-1 is thought to promote recruitment of mRNA export factor to mRNAs. | Paper_evidence | WBPaper00013477 | |||||
WBPaper00030790 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 24 Jul 2012 00:00:00 | ||||||||
Automated_description | Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Is an ortholog of human ALYREF (Aly/REF export factor). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C01F6.5 | |||||||
Corresponding_transcript | C01F6.5.1 | ||||||||
Other_sequence | CBC17281_1 | ||||||||
Associated_feature | WBsf646214 | ||||||||
WBsf655036 | |||||||||
WBsf997356 | |||||||||
WBsf997357 | |||||||||
WBsf1017926 | |||||||||
WBsf1017927 | |||||||||
WBsf228787 | |||||||||
Experimental_info | RNAi_result (15) | ||||||||
Expr_pattern | Expr13878 | ||||||||
Expr1022895 | |||||||||
Expr1030066 | |||||||||
Expr1143427 | |||||||||
Expr2009316 | |||||||||
Expr2027552 | |||||||||
Drives_construct | WBCnstr00017948 | ||||||||
Construct_product (3) | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (173) | |||||||||
Interaction (221) | |||||||||
Map_info | Map | IV | Position | 4.05043 | Error | 0.00037 | |||
Positive | Positive_clone | C01F6 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (25) | |||||||||
Remark (2) | |||||||||
Method | Gene |