WormBase Tree Display for Gene: WBGene00000120
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WBGene00000120 | SMap | S_parent | Sequence | C01F6 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | aly-1 | Person_evidence | WBPerson297 | |||
WBPerson4981 | |||||||
Sequence_name | C01F6.5 | ||||||
Molecular_name | C01F6.5 | ||||||
C01F6.5.1 | |||||||
CE02954 | |||||||
Other_name | ref-1 | Paper_evidence | WBPaper00013477 | ||||
CELE_C01F6.5 | Accession_evidence | NDB | BX284604 | ||||
Public_name | aly-1 | ||||||
DB_info | Database | AceView | gene | 4J873 | |||
WormQTL | gene | WBGene00000120 | |||||
WormFlux | gene | WBGene00000120 | |||||
NDB | locus_tag | CELE_C01F6.5 | |||||
Panther | gene | CAEEL|WormBase=WBGene00000120|UniProtKB=Q17561 | |||||
family | PTHR19965 | ||||||
NCBI | gene | 177735 | |||||
RefSeq | protein | NM_069187.8 | |||||
TREEFAM | TREEFAM_ID | TF313312 | |||||
TrEMBL | UniProtAcc | Q17561 | |||||
UniProt_GCRP | UniProtAcc | Q17561 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | aly | ||||||
Allele (20) | |||||||
Strain | WBStrain00032271 | ||||||
WBStrain00037646 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00058513 | ||||||
00058514 | |||||||
00058515 | |||||||
00058516 | |||||||
00106834 | |||||||
Ortholog (59) | |||||||
Paralog | WBGene00000121 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00000122 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00015329 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | aly-1 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-1 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-2 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-2, ALY-1 and its paralog ALY-2 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; ALY-1 and NXF-2 bind the TRE element in vitro; ALY-1 is also bound competitively by either NXF-2 or TRA-1 in vitro; aly-1(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-1 is thought to promote recruitment of mRNA export factor to mRNAs. | Paper_evidence | WBPaper00013477 | |||
WBPaper00030790 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 24 Jul 2012 00:00:00 | ||||||
Automated_description | Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Is an ortholog of human ALYREF (Aly/REF export factor). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C01F6.5 | |||||
Corresponding_transcript | C01F6.5.1 | ||||||
Other_sequence | CBC17281_1 | ||||||
Associated_feature | WBsf646214 | ||||||
WBsf655036 | |||||||
WBsf997356 | |||||||
WBsf997357 | |||||||
WBsf1017926 | |||||||
WBsf1017927 | |||||||
WBsf228787 | |||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern (6) | |||||||
Drives_construct | WBCnstr00017948 | ||||||
Construct_product | WBCnstr00016846 | ||||||
WBCnstr00017948 | |||||||
WBCnstr00040226 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (173) | |||||||
Interaction (221) | |||||||
Map_info | Map | IV | Position | 4.05043 | Error | 0.00037 | |
Positive | Positive_clone | C01F6 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (25) | |||||||
Remark | Published as ref-1. The CGC approved ref-1 is a different sequence with ID WBGene00004334 | Paper_evidence | WBPaper00013477 | ||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |