WormBase Tree Display for Gene: WBGene00000068
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| WBGene00000068 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F17C8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | acy-1 | Person_evidence | WBPerson1139 | |||||
| Sequence_name | F17C8.1 | ||||||||
| Molecular_name | F17C8.1 | ||||||||
| F17C8.1.1 | |||||||||
| CE00955 | |||||||||
| Other_name | sgs-1 | ||||||||
| CELE_F17C8.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | acy-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | acy | ||||||||
| Allele (122) | |||||||||
| Legacy_information | [Berger AJ, Kaplan JM] nu327 is semidominant suppressor of neurodegeneration induced by constitutive G alpha s. No conspicuous behavioral or other phenotype, odorant response to isoamyl alcohol slightly impaired. OA2: nu329, nu343 similar. Encodes adenylyl cyclase, 40% identical to mammalian adenylyl cyclases. nu327 missense, nu329 and nu343 splice donor mutations. Predicted gene F17C8.1 | ||||||||
| [Korswagen HC] pk301 (pka sgs-1) suppresses neuronal degeneration induced by activated G alpha s. No obvious defects in development or behavior. Loss-of-function mutation in predicted adenylyl cyclase. OA8: pk310, pk311, pk450::Tc1, etc., all similar. | |||||||||
| Strain (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (34) | |||||||||
| Paralog (36) | |||||||||
| Structured_description | Concise_description | acy-1 encodes an adenylyl cyclase that is most closely related to the divergent mouse isoform type IX; acy-1 is required for viability, muscle contraction, locomotion, molting, and regulation of sleep-like behavior (lethargus) during larval development; acy-1 acts genetically downstream of gsa-1 and is expressed in excitable cells. | Paper_evidence | WBPaper00003038 | |||||
| WBPaper00003207 | |||||||||
| WBPaper00031383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Nov 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in plasma membrane. Expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in mood disorder. Is an ortholog of human ADCY9 (adenylate cyclase 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:240) | ||||
| Molecular_info | Corresponding_CDS | F17C8.1 | |||||||
| Corresponding_transcript | F17C8.1.1 | ||||||||
| Other_sequence (201) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr592 | ||||||||
| Expr1436 | |||||||||
| Expr14482 | |||||||||
| Expr1015096 | |||||||||
| Expr1030029 | |||||||||
| Expr1148848 | |||||||||
| Expr2009227 | |||||||||
| Expr2027464 | |||||||||
| Drives_construct | WBCnstr00000278 | ||||||||
| WBCnstr00010276 | |||||||||
| WBCnstr00015084 | |||||||||
| WBCnstr00037756 | |||||||||
| WBCnstr00040905 | |||||||||
| Construct_product | WBCnstr00000256 | ||||||||
| WBCnstr00000257 | |||||||||
| WBCnstr00000259 | |||||||||
| WBCnstr00006300 | |||||||||
| WBCnstr00010276 | |||||||||
| WBCnstr00014688 | |||||||||
| WBCnstr00037756 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (184) | |||||||||
| Interaction (11) | |||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000120 | |||||||||
| Map_info | Map | III | Position | -2.649 | Error | 0.036999 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F17C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3712 | |||||||
| 4625 | |||||||||
| Reference (62) | |||||||||
| Remark | Data extracted from Berger et al. (1998) | ||||||||
| Data extracted from Korswagen et al. (1998) | |||||||||
| Sequence connection from [Berger AJ] | |||||||||
| Positive_clone F17C8 is based on cosmid rescue, mutant sequence [Berger AJ, Kaplan JM, Korswagen HC][[030403 ck1] | |||||||||
| Method | Gene |
