WormBase Tree Display for Gene: WBGene00000068

WBGene00000068 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F17C8
  Identity: Version: 1
    Name: CGC_name: acy-1 Person_evidence: WBPerson1139
      Sequence_name: F17C8.1
      Molecular_name: F17C8.1
        F17C8.1.1
        CE00955
      Other_name: sgs-1
        CELE_F17C8.1 Accession_evidence: NDB BX284603
      Public_name: acy-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acy
    Allele (122)
    Legacy_information: [Berger AJ, Kaplan JM] nu327 is semidominant suppressor of neurodegeneration induced by constitutive G alpha s. No conspicuous behavioral or other phenotype, odorant response to isoamyl alcohol slightly impaired. OA2: nu329, nu343 similar. Encodes adenylyl cyclase, 40% identical to mammalian adenylyl cyclases. nu327 missense, nu329 and nu343 splice donor mutations. Predicted gene F17C8.1
      [Korswagen HC] pk301 (pka sgs-1) suppresses neuronal degeneration induced by activated G alpha s. No obvious defects in development or behavior. Loss-of-function mutation in predicted adenylyl cyclase. OA8: pk310, pk311, pk450::Tc1, etc., all similar.
    Strain (14)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog: WBGene00061719 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00037499 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00139513 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00223675 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g5964 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6297 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1602 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g20421 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g23325 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g20291 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g12898 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g17051 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g14860 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g1249 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00712.g13623 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_01110.g15711 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-acy-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold478.g1792 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_02967.g28576 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_22462 Caenorhabditis latens From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05085 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g1493 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30066200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g7523 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00122091 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00244897 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00092076 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00262293 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00290634 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0022710 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050208-455 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:240 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:108450 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1304747 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (36)
    Structured_description: Concise_description: acy-1 encodes an adenylyl cyclase that is most closely related to the divergent mouse isoform type IX; acy-1 is required for viability, muscle contraction, locomotion, molting, and regulation of sleep-like behavior (lethargus) during larval development; acy-1 acts genetically downstream of gsa-1 and is expressed in excitable cells. Paper_evidence: WBPaper00003038
            WBPaper00003207
            WBPaper00031383
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 06 Nov 2008 00:00:00
      Automated_description: Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in plasma membrane. Expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in mood disorder. Is an ortholog of human ADCY9 (adenylate cyclase 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:240)
  Molecular_info: Corresponding_CDS: F17C8.1
    Corresponding_transcript: F17C8.1.1
    Other_sequence (201)
    Associated_feature (11)
  Experimental_info: RNAi_result (19)
    Expr_pattern: Expr592
      Expr1436
      Expr14482
      Expr1015096
      Expr1030029
      Expr1148848
      Expr2009227
      Expr2027464
    Drives_construct: WBCnstr00000278
      WBCnstr00010276
      WBCnstr00015084
      WBCnstr00037756
      WBCnstr00040905
    Construct_product: WBCnstr00000256
      WBCnstr00000257
      WBCnstr00000259
      WBCnstr00006300
      WBCnstr00010276
      WBCnstr00014688
      WBCnstr00037756
    Microarray_results (19)
    Expression_cluster (184)
    Interaction (11)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
      WBbiopr:00000120
  Map_info: Map: III Position: -2.649 Error: 0.036999
    Well_ordered
    Positive: Positive_clone: F17C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3712
        4625
  Reference (62)
  Remark: Data extracted from Berger et al. (1998)
    Data extracted from Korswagen et al. (1998)
    Sequence connection from [Berger AJ]
    Positive_clone F17C8 is based on cosmid rescue, mutant sequence [Berger AJ, Kaplan JM, Korswagen HC][[030403 ck1]
  Method: Gene