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WormBase Tree Display for Gene: WBGene00000064

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Name Class

WBGene00000064SMapS_parentSequenceT04C12
IdentityVersion1
NameCGC_nameact-2Person_evidenceWBPerson259
Sequence_nameT04C12.5
Molecular_nameT04C12.5
T04C12.5.1
CE13150
Other_nameact2Accession_evidenceEMBLX16797
CELE_T04C12.5Accession_evidenceNDBBX284605
Public_nameact-2
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:19WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classact
Allele (25)
Strain (7)
In_clusteract-123
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (57)
Paralog (11)
Structured_descriptionConcise_descriptionact-2 encodes one of five C. elegans actins; act-2 functions redundantly in early embryonic cortical microfilaments with act-1 and act-3, and dominant mutations in act-2 result in uncoordinated locomotion; an ACT-2::GFP reporter fusion is expressed in the cytoplasm of embryonic cells and is also found in contractile filaments in adult muscle cells.Paper_evidenceWBPaper00001178
WBPaper00001709
WBPaper00027028
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated29 May 2013 00:00:00
Automated_descriptionPredicted to enable ATP binding activity. Involved in several processes, including cortical actin cytoskeleton organization; cytoskeleton-dependent cytokinesis; and embryo development. Located in actin filament and cell cortex. Expressed in body wall musculature; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:1588Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:132)
DOID:0081113Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:144)
DOID:10881Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:132)
DOID:0081112Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:132)
DOID:0110550Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:144)
Molecular_infoCorresponding_CDST04C12.5
Corresponding_transcriptT04C12.5.1
Other_sequenceEX537974.1
HBC27667_1
FG981032.1
ES411932.1
BE217711.1
EX011850.1
MI02623
MI01030
JI181420.1
FC814430.1
EX007952.1
EX912462.1
ES408725.1
ZPC00041_1
JO472453.1
TM01500
ASC02463_1
FG975857.1
EX914716.1
MH09133
BU586890.1
AI061564.1
BM567610.1
PSC04662_1
GE637961.1
GE626596.1
TS00914
ASC25990_1
HG04891
EX537783.1
ES739971.1
MH02791
MCC00987_1
GR978633.1
ASC32350_1
FG975863.1
EX910026.1
PT04904
ES744656.1
SR01096
EX911631.1
ASC04191_1
JO475834.1
TM01175
ES880307.1
EX911473.1
FC815954.1
FG972955.1
FC817144.1
TLC00136_1
EL887721.1
AS08532
EX911518.1
FE915613.1
DI00070
MIC05854_1
MI02634
ACC07885_1
CJC18251_1
MH07872
JO468407.1
ES412487.1
MH09228
JI215635.1
PT00797
ZP00071
GW410303.1
GE637913.1
Acan_isotig06548
EF571443.1
MIC00350_2
EX543540.1
FG976481.1
ES743009.1
CBC06446_1
SS01393
FC810875.1
FG588348.1
CK855065.1
EX914400.1
AE03487
EX007263.1
AYC02944_1
BXC06354_1
EX013574.1
GE638027.1
EX013734.1
ES880318.1
BU585895.1
EX007002.1
CV199747.1
EL890522.1
EX549346.1
BE239059.1
BE238888.1
AS03386
FC813579.1
GPC00316_1
EX912659.1
TMC02921_1
MH09446
TM03260
AAC00374_1
CD455229.1
FC811584.1
GE638263.1
GE638142.1
MH09303
SS02534
HBC01402_1
PSC04111_1
EX008269.1
GO239459.1
ES742799.1
EX012764.1
GW411049.1
FF679302.1
SSC00848_1
AI444891.1
HBC01068_1
EX015281.1
BU586566.1
GO239505.1
BMC01680_1
SSC02731_1
ES413841.1
EX911264.1
ES744254.1
HGC04228_1
EH005623.1
MCC03285_1
FE916348.1
EX013053.1
BMC01127_1
FG973483.1
FG978661.1
WBC00844_2
FG348740.1
GW413507.1
AI130298.1
AA682177.1
BU586129.1
BF727542.1
ES412496.1
FK807866.1
GO239965.1
GP00828
ES739043.1
ACC03572_1
ZPC00003_2
GW406639.1
AS00396
PTC00500_2
AS09542
EX911908.1
AA917225.1
EX912935.1
PSC00457
MHC11942_1
PT04372
SS01563
EX912789.1
PTC04100_1
FF678108.1
CJC14769_1
MJ00659
MJC01140_1
HBC00098_3
FE915588.1
FE916324.1
EX010970.1
EX914255.1
ASC00847_2
ASC06056_1
FG352332.1
PT00671
JI252359.1
MH09461
FG580884.1
TCC02388
EX911169.1
BG734343.1
EL888013.1
AF532605.1
MJ02145
FG971947.1
PT04885
U40590.1
ES409655.1
GW409409.1
FC814698.1
JI176476.1
MH06955
CK854717.1
FC811288.1
BE636513.1
BG264119.1
FC820489.1
FG975697.1
FC810778.1
AI058124.1
MH09159
FK809595.1
GPC00632_1
HBC14965_1
GW409607.1
JO475725.1
CK850112.1
JI211280.1
MIC00350_1
TS03469
MJ00260
EX008108.1
TX00130
GW412522.1
MIC07632_1
HBC18166_1
MH06272
ES743030.1
MAC02930_1
FG972085.1
BMC12039_1
EX545188.1
SRC07178_1
ES412252.1
HBC15654_1
EX537767.1
ES570138.1
FG972765.1
MIC02553_1
AS10561
MJC01140_2
GW412760.1
FC812288.1
MHC09307_1
ACC36504_1
ES740698.1
PT03291
GE626564.1
Acan_isotig02497
PT04820
EU368944.1
EX013919.1
FG619706.1
MH07354
TSC07054_1
BE239001.1
Hbac_isotig01681
EX913665.1
EX536859.1
FK808431.1
EX013770.1
EV850795.1
BE720887.1
FF680699.1
GP01014
EV853179.1
EX912565.1
FE916126.1
EX013819.1
GO239843.1
FG973619.1
MPC00467_1
FE910781.1
FG980116.1
FC811480.1
Tcol_isotig00476
GP00765
ES740240.1
BM567632.1
MH09463
TMC01174_1
FG581324.1
MI02548
Dviv_isotig23298
CBC04629_1
PTC04226_1
EL889255.1
FC811721.1
ES739394.1
DV019479.1
FG588067.1
MHC11864_1
GW406996.1
GW408370.1
GW412406.1
AS00636
BMC07213_1
SSC06115_1
BE638383.1
GO239890.1
FE915866.1
FC817018.1
CJC01711_1
BU586065.1
MHC05768_1
HG09664
GW413418.1
EV849982.1
FC816794.1
DVC00878_1
FF679602.1
GPC00411_1
PT02795
EX008506.1
SSC02731_2
DV019697.1
CR02690
EX008277.1
AS09322
CBC00193_3
EX009194.1
BU585570.1
ES743620.1
EX009105.1
EX913085.1
ES740696.1
MH07209
JI218910.1
MH04052
BE225407.1
GE638203.1
CRC00044_4
EX546118.1
MJ00521
FC817916.1
EX916284.1
TLC00017_1
BU586305.1
JI229500.1
FE916804.1
FK800995.1
AIC00012_1
FG973880.1
HBC14296_1
FK809625.1
AS00757
MH02790
JI476856.1
BF049856.1
Dviv_isotig30845
EX555927.1
XIC00150_1
FG975009.1
GW407959.1
TSC00186_1
ES742914.1
FC811825.1
FC811043.1
EX008104.1
ES743442.1
ES741955.1
MP00245
ES410592.1
ES569048.1
GP00322
FC540756.1
FE907114.1
GW410555.1
AYC01831_1
FG582925.1
CV200399.1
FG585934.1
Acan_isotig02499
FG352596.1
MHC00211_2
FC810529.1
HCC12158_1
FK803944.1
FG972928.1
EH005369.1
EX915480.1
HO243979.1
Oden_isotig19833
GO240189.1
MHC04453_1
ES880360.1
GW413328.1
GW407651.1
Dviv_isotig00408
OOC00001_1
ES412484.1
OVC09945_1
HGC11844_1
JO473756.1
BE238884.1
EH005355.1
MH09234
FC541074.1
Tcol_isotig12464
JO473950.1
JO468499.1
MIC00350_3
MH09233
PVC00671_1
SRC08278_1
GO240543.1
BMC00007_1
EX910476.1
ES412585.1
CBC07014_1
SRC01393_1
EX011145.1
ZPC00162_1
BU586630.1
MH09132
EX916244.1
CK850716.1
MC01192
EX013167.1
ES413998.1
MJ00746
ZP00076
AY672703.1
AS08091
AW980218.1
GW407797.1
FF678126.1
PT04825
CA303842.1
XI01343
HBC01068_2
ACC31188_1
FC809506.1
TS03380
DN190249.1
EX914021.1
ES411383.1
MA00151
BU587014.1
GW409920.1
TLC00032_1
ACC15743_1
EX012314.1
ASC07236_1
EX553877.1
EX914458.1
EX916066.1
HG09470
EX014631.1
ES739098.1
HO348264.1
ES411567.1
PTC00500_4
EX915737.1
GW409906.1
ASC28472_1
EX539304.1
CK850227.1
SC00924
PTC04434_1
EX914330.1
MI01094
JO475637.1
GR12295
HC08970
PTC04399_1
GO240379.1
EX010965.1
ALC00497_1
ES740776.1
GPC00502_1
AI130581.1
EV852743.1
AS05035
OVC08915_1
GW407433.1
MIC06077_1
PT04672
EX915245.1
HGC05569_1
CGC01055_1
HG08802
LLC00014_1
EX538461.1
ASC01849_1
Associated_feature (16)
Experimental_infoRNAi_result (49)
Expr_patternExpr3813
Expr4555
Expr1030025
Expr1155999
Expr2009222
Expr2027459
Drives_constructWBCnstr00011672
WBCnstr00016094
WBCnstr00037759
Construct_productWBCnstr00011672
WBCnstr00016094
WBCnstr00037759
AntibodyWBAntibody00001783
Microarray_results (23)
Expression_cluster (206)
Interaction (415)
WBProcessWBbiopr:00000096
Map_infoMapVPosition2.94351Error0.003498
PositivePositive_cloneT04C12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point6177
6203
Multi_point4140
4141
Reference (62)
RemarkM03F4.2 connection removed since latter is on another chromosome. [sdm 0107]
Sequences T04C12.4 & T04C12.6 removed. email from JAH 0109
MethodGene