WormBase Tree Display for Gene: WBGene00000064
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WBGene00000064 | SMap | S_parent | Sequence | T04C12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | act | ||||||
Allele (25) | |||||||
Strain | WBStrain00031881 | ||||||
WBStrain00005465 | |||||||
WBStrain00007342 | |||||||
WBStrain00007350 | |||||||
WBStrain00007351 | |||||||
WBStrain00007357 | |||||||
WBStrain00007359 | |||||||
In_cluster | act-123 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (57) | |||||||
Paralog (11) | |||||||
Structured_description | Concise_description | act-2 encodes one of five C. elegans actins; act-2 functions redundantly in early embryonic cortical microfilaments with act-1 and act-3, and dominant mutations in act-2 result in uncoordinated locomotion; an ACT-2::GFP reporter fusion is expressed in the cytoplasm of embryonic cells and is also found in contractile filaments in adult muscle cells. | Paper_evidence | WBPaper00001178 | |||
WBPaper00001709 | |||||||
WBPaper00027028 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 29 May 2013 00:00:00 | ||||||
Automated_description | Predicted to enable ATP binding activity. Involved in several processes, including cortical actin cytoskeleton organization; cytoskeleton-dependent cytokinesis; and embryo development. Located in actin filament and cell cortex. Expressed in body wall musculature; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; and autosomal dominant nonsyndromic deafness 20. Is an ortholog of human ACTB (actin beta). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:1588 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||
DOID:0081113 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) | ||||
DOID:10881 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||
DOID:0081112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:132) | ||||
DOID:0110550 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:144) | ||||
Molecular_info | Corresponding_CDS | T04C12.5 | |||||
Corresponding_transcript | T04C12.5.1 | ||||||
Other_sequence (476) | |||||||
Associated_feature (16) | |||||||
Experimental_info | RNAi_result (49) | ||||||
Expr_pattern | Expr3813 | ||||||
Expr4555 | |||||||
Expr1030025 | |||||||
Expr1155999 | |||||||
Expr2009222 | |||||||
Expr2027459 | |||||||
Drives_construct | WBCnstr00011672 | ||||||
WBCnstr00016094 | |||||||
WBCnstr00037759 | |||||||
Construct_product | WBCnstr00011672 | ||||||
WBCnstr00016094 | |||||||
WBCnstr00037759 | |||||||
Antibody | WBAntibody00001783 | ||||||
Microarray_results (23) | |||||||
Expression_cluster (206) | |||||||
Interaction (415) | |||||||
WBProcess | WBbiopr:00000096 | ||||||
Map_info | Map | V | Position | 2.94351 | Error | 0.003498 | |
Positive | Positive_clone | T04C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 6177 | |||||
6203 | |||||||
Multi_point | 4140 | ||||||
4141 | |||||||
Reference (62) | |||||||
Remark | M03F4.2 connection removed since latter is on another chromosome. [sdm 0107] | ||||||
Sequences T04C12.4 & T04C12.6 removed. email from JAH 0109 | |||||||
Method | Gene |