WormBase Tree Display for Gene: WBGene00000042

WBGene00000042 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: acr-2 Person_evidence: WBPerson1430
      Sequence_name: K11G12.2
      Molecular_name: K11G12.2
        K11G12.2.1
        CE07380
      Other_name: CELE_K11G12.2 Accession_evidence: NDB BX284606
      Public_name: acr-2
    DB_info: Database: AceView gene XH327
        WormQTL gene WBGene00000042
        WormFlux gene WBGene00000042
        NDB locus_tag CELE_K11G12.2
        Panther gene CAEEL|WormBase=WBGene00000042|UniProtKB=P48182
          family PTHR18945
        NCBI gene 180936
        RefSeq protein NM_076727.9
        SwissProt UniProtAcc P48182
        UniProt_GCRP UniProtAcc P48182
        OMIM gene 118503
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acr
    Allele (133)
    Legacy_information: [C.elegansII] NMK. Structural and functional similarity to non-alpha subunit of nicotinic acetylcholine receptor. [CGC]
    Strain: WBStrain00005354
      WBStrain00032255
      WBStrain00005418
      WBStrain00047355
      WBStrain00051638
    RNASeq_FPKM (74)
    GO_annotation (44)
    Contained_in_operon: CEOPX158
    Ortholog (48)
    Paralog (100)
    Structured_description: Concise_description: A homolog of a non-alpha type nicotinic acetylcholine receptor subunit that forms a functional channel when co-expressed with the unc-38 alpha subunit. Paper_evidence: WBPaper00002294
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; neuromuscular synaptic transmission; and positive regulation of translation. Located in neuron projection. Expressed in AVE; DVB; cholinergic neurons; somatic nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in lung disease (multiple); nicotine dependence; and stomach cancer. Is an ortholog of human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3905 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:5409 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:0050742 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
  Molecular_info: Corresponding_CDS: K11G12.2
    Corresponding_transcript: K11G12.2.1
    Other_sequence (16)
    Associated_feature: WBsf648253
      WBsf235861
  Experimental_info: RNAi_result: WBRNAi00030261 Inferred_automatically: RNAi_primary
      WBRNAi00066397 Inferred_automatically: RNAi_primary
      WBRNAi00017018 Inferred_automatically: RNAi_primary
      WBRNAi00050610 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8872
      Expr9149
      Expr9150
      Expr10808
      Expr10809
      Expr15314
      Expr1017800
      Expr1154318
      Expr2009192
      Expr2027430
    Drives_construct (51)
    Construct_product (12)
    Regulate_expr_cluster: WBPaper00059763:neuron_acr-2(n2420gf)_regulated
    Microarray_results (21)
    Expression_cluster (122)
    Interaction (45)
  Map_info: Map: X Position: -2.55794 Error: 0.003166
    Positive: Positive_clone: F38B6 Person_evidence: WBPerson51
        JF#WA56 Person_evidence: WBPerson51
        K11G12 Person_evidence: WBPerson51
          Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (59)
  Remark: data from H Baylis, University of Cambridge
    [Baylis HA] Acr-2 and acr-3 were identified on the phage JF#WA56 located on chromosome X. Subsequently the cosmid K11G12 has been sequenced. The predicted protein K11G12.2 is a concatenated version of acr-2 and acr-3. The sequence of acr-2 cDNA is in EMBL:CEACR2 (X86403). The 5' end of the acr-2 cDNA is on the adjacent cosmid F38B6.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene