WormBase Tree Display for Gene: WBGene00000040
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| WBGene00000040 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | ZK455 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | aco-1 | |||||||
| Sequence_name | ZK455.1 | ||||||||
| Molecular_name | ZK455.1 | ||||||||
| ZK455.1.1 | |||||||||
| CE03812 | |||||||||
| Other_name | gei-22 | CGC_data_submission | |||||||
| CELE_ZK455.1 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | aco-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aco | ||||||||
| Allele (72) | |||||||||
| Strain | WBStrain00023533 | ||||||||
| WBStrain00031712 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00000041 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; aco-1 mRNA levels appear to decrease in response to iron treatment; an ACO-1::GFP fusion protein exhibits cytosolic expression in the hypodermal seam cells and the intestine. | Paper_evidence | WBPaper00004424 | |||||
| WBPaper00005194 | |||||||||
| WBPaper00005703 | |||||||||
| WBPaper00024456 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Dec 2012 00:00:00 | ||||||||
| Automated_description | Enables aconitate hydratase activity. Involved in tricarboxylic acid metabolic process. Located in cytosol. Expressed in seam cell. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human ACO1 (aconitase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6115) | ||||
| Molecular_info | Corresponding_CDS | ZK455.1 | |||||||
| Corresponding_transcript | ZK455.1.1 | ||||||||
| Other_sequence (60) | |||||||||
| Associated_feature | WBsf648536 | ||||||||
| WBsf648537 | |||||||||
| WBsf655212 | |||||||||
| WBsf663332 | |||||||||
| WBsf236371 | |||||||||
| WBsf236372 | |||||||||
| WBsf236373 | |||||||||
| WBsf236374 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00038297 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00115744 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059431 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00115745 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00024298 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr434 | ||||||||
| Expr2296 | |||||||||
| Expr2353 | |||||||||
| Expr1021359 | |||||||||
| Expr1030020 | |||||||||
| Expr1162858 | |||||||||
| Expr2009164 | |||||||||
| Expr2027401 | |||||||||
| Drives_construct | WBCnstr00010755 | ||||||||
| WBCnstr00010787 | |||||||||
| WBCnstr00018300 | |||||||||
| WBCnstr00037777 | |||||||||
| Construct_product | WBCnstr00010755 | ||||||||
| WBCnstr00010787 | |||||||||
| WBCnstr00037777 | |||||||||
| Antibody | WBAntibody00000600 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (219) | |||||||||
| Interaction (90) | |||||||||
| Map_info | Map | X | Position | 3.01054 | Error | 0.014051 | |||
| Positive | Positive_clone | ZK455 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4663 | |||||||
| 5397 | |||||||||
| 5493 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (21) | |||||||||
| Remark | gei-22 becomes an other name for this gene, main name is aco-1 [JAH][011204 ck1] | ||||||||
| Sequence connection from [Qadota H, Kaibuchi K] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
