WormBase Tree Display for Gene: HGNC:14261
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| HGNC:14261 | Identity | Name | CGC_name | Rgs18 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name | RGD:1315187 | |||||
| Rgs13 | ||||||
| regulator of G-protein signaling 18 | ||||||
| regulator of G-protein signalling 13 | ||||||
| regulator of G-protein signalling 18 | ||||||
| Public_name | Rgs18 | |||||
| DB_info | Database | HGNC | id | 14261 | ||
| AGR | cURI | HGNC:14261 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000150681 | ||||
| UniProt | UniProt_AC | Q9NS28 | ||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00004350 | Caenorhabditis elegans | From_analysis | OrthoFinder | ||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00004353 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
| Panther | ||||||
| PhylomeDB | ||||||
| Structured_description | Automated_description | This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] | Inferred_automatically | AGR_import |
