WormBase Tree Display for Gene: HGNC:14261
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HGNC:14261 | Identity (4) | |||||
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Gene_info | Biotype | SO:0001217 | ||||
Ortholog | WBGene00004350 | Caenorhabditis elegans | From_analysis | OrthoFinder | ||
Panther | ||||||
PhylomeDB | ||||||
WBGene00004353 | Caenorhabditis elegans | From_analysis | OrthoFinder | |||
Panther | ||||||
PhylomeDB | ||||||
Structured_description | Automated_description | This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] | Inferred_automatically | AGR_import |