WormBase Tree Display for Expr_pattern: Expr2307
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| Expr2307 | Expression_of | Gene | WBGene00001130 |
|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00001130 | ||
| Expression_data | GO_term | GO:0030496 | |
| GO:0032154 | |||
| GO:0005876 | |||
| GO:0031410 | |||
| Subcellular_localization | By immunostaining early embryos with an antibody specific for the C. elegans dynamin homolog, the C. elegans homolog to conventional dynamin was shown localized to mitotic spindles. During metaphase/early anaphase, dynamin was markedly concentrated around the metaphase plate and was also present on several large cytoplasmic vesicles. Later in anaphase, dynamin became concentrated equatorially and also localized along spindle microtubules in a manner similar to the localization of dynamin along spindle microtubules in mammalian cells. Further, in C. elegans embryos, dynamin localized to the newly formed cleavage furrow and accumulated at the midbody as the embryos progressed through the early and late stages of cytokinesis. | ||
| Type | Antibody | Anti-DYN-1 antibody. | |
| Picture | WBPicture0000009731 | ||
| Remark | Treatment of C. elegans embryos and gonads with dyn-1 RNAi resulted in a depletion of dynamin staining, as observed by immunofluorescence staining, indicating that the dynamin gene was targeted by using RNAi and that dynamin protein expression was reduced. In addition, this observation supports the specificity of the dynamin antibody used in this study. | ||
| Reference | WBPaper00005664 | ||
| Antibody_info | WBAntibody00000197 |
