WormBase Tree Display for Expr_pattern: Expr11272
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| Expr11272 | Expression_of | Gene | WBGene00011648 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00011648 | |||
| Expression_data | Anatomy_term | WBbt:0003869 | Certain | |
| WBbt:0003870 | Certain | |||
| WBbt:0005735 | Certain | |||
| GO_term | GO:0045202 | |||
| GO:0043005 | ||||
| GO:0005783 | ||||
| GO:0005794 | ||||
| GO:0043025 | ||||
| GO:0032589 | ||||
| GO:0070971 | ||||
| Subcellular_localization | CNI-1 and GLR-1 were in close apposition to SEC-24/COPII puncta, which mark putative ER export sites. | |||
| CNI-1 was also expressed in the processes of AVA, where it was distributed in a punctate pattern that colocalized with the ER/Golgi marker, PISY-1. The punctate colocalization of GLR-1 with CNI-1 suggests that CNI-1 might also function at synapses and that is expressed on the cell surface. Surface expression of CNI-1 was also supported by in vivo antibody labeling experiments. These results indicate that CNI-1 is not restricted to the cell body or intracellular organelles and that CNI-1 is present at synapses. | ||||
| In neuronal cell bodies, CNI-1::GFP appeared punctate and distinctively clustered at perinuclear sites, suggestive of localization to the ER. By colocalization studies the authors confirmed that CNI-1 is expressed in discrete regions of the ER/Golgi where it colocalized with GLR-1. | ||||
| Type | Reporter_gene | |||
| Pattern | Expression of pcni-1::GFP was found in many tissues, including widespread distribution in the nervous system. CNI-1 was expressed in all GLR-1-expressing neurons, including AVA. | |||
| Picture | WBPicture0000013485 | |||
| WBPicture0000013486 | ||||
| WBPicture0000013487 | ||||
| WBPicture0000013488 | ||||
| Reference | WBPaper00044271 | |||
| Transgene | WBTransgene00019052 |
