WormBase Tree Display for Expr_pattern: Expr11272
expand all nodes | collapse all nodes | view schema
Expr11272 | Expression_of | Gene | WBGene00011648 |
---|---|---|---|
Reflects_endogenous_expression_of | WBGene00011648 | ||
Expression_data (2) | |||
Subcellular_localization | CNI-1 and GLR-1 were in close apposition to SEC-24/COPII puncta, which mark putative ER export sites. | ||
CNI-1 was also expressed in the processes of AVA, where it was distributed in a punctate pattern that colocalized with the ER/Golgi marker, PISY-1. The punctate colocalization of GLR-1 with CNI-1 suggests that CNI-1 might also function at synapses and that is expressed on the cell surface. Surface expression of CNI-1 was also supported by in vivo antibody labeling experiments. These results indicate that CNI-1 is not restricted to the cell body or intracellular organelles and that CNI-1 is present at synapses. | |||
In neuronal cell bodies, CNI-1::GFP appeared punctate and distinctively clustered at perinuclear sites, suggestive of localization to the ER. By colocalization studies the authors confirmed that CNI-1 is expressed in discrete regions of the ER/Golgi where it colocalized with GLR-1. | |||
Type | Reporter_gene | ||
Pattern | Expression of pcni-1::GFP was found in many tissues, including widespread distribution in the nervous system. CNI-1 was expressed in all GLR-1-expressing neurons, including AVA. | ||
Picture | WBPicture0000013485 | ||
WBPicture0000013486 | |||
WBPicture0000013487 | |||
WBPicture0000013488 | |||
Reference | WBPaper00044271 | ||
Transgene | WBTransgene00019052 |