WormBase Tree Display for Variation: WBVar00091915

WBVar00091915 Name: Public_name: ok631
    Other_name: C08F8.8.1:c.366+309_806+23del
    HGVSg: CHROMOSOME_IV:g.11172510_11173661del
  Sequence_details: SMap: S_parent: Sequence: C08F8
    Flanking_sequences: aggtgaaaagttgtcggttgctgtacaaat ttttcaattttcttatttttggaataatgt
    Mapping_target: C08F8
    Type_of_mutation: Deletion
    PCR_product: ok631_external
      ok631_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00029536
      WBStrain00035755
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00196519
      WBGene00003657
    Transcript: C08F8.8.1 VEP_consequence: splice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
        VEP_impact: HIGH
        HGVSc: C08F8.8.1:c.366+309_806+23del
        Intron_number: 5-7/9
        Exon_number: 6-7/10
      C08F8.10 VEP_consequence: non_coding_transcript_exon_variant
        VEP_impact: MODIFIER
        cDNA_position: ?-30
        Exon_number: 1/1
    Interactor: WBInteraction000504024
  Isolation: Mutagen: UV/TMP
  Genetics: Mapping_data: In_multi_point: 4526
  Description: Phenotype: WBPhenotype:0000050 Paper_evidence: WBPaper00035106
        Curator_confirmed: WBPerson2021
        Remark: Emb Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035106
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000054 Paper_evidence: WBPaper00035106
        Curator_confirmed: WBPerson2021
        Remark: Early larval arrest phenotype Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035106
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000073 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Arrested L1 larvae displayed variable defects in tail morphology, including kinks, bulges, and forks. Tail morphology defects were not observed in later stage escapers. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
      WBPhenotype:0000081 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Homozygous mutants usually arrested development as embryos or L1 larvae. Homozygous ok631 adult escapers were never recovered. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00039839
                Curator_confirmed: WBPerson712
      WBPhenotype:0000134 Paper_evidence: WBPaper00035106
        Curator_confirmed: WBPerson2021
        Remark: In lsy-9 mutants, che-1 expression is lost in a large fraction of animals Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035106
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: che-1::yfp (otIs188) Paper_evidence: WBPaper00035106
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000354 Paper_evidence: WBPaper00035106
        Curator_confirmed: WBPerson2021
        Remark: Loss of bilaterally expressed markers reveals overall differentiation defect of ASE Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035106
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: ceh-36 (otIs151), flp-6 (otIs125), che-1 (otIs188), osm-6 (oyIs59) Paper_evidence: WBPaper00035106
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000643 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Arrested L1 appeared slightly uncoordinated in comparison to heterozygous sisters. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
      WBPhenotype:0000704 Paper_evidence: WBPaper00035106
        Curator_confirmed: WBPerson2021
        Remark: The excretory canal cell displayed cystic phenotypes Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035106
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: pes-6::gfp (bgIs312) Paper_evidence: WBPaper00035106
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000708 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Arrested L1 larvae had grossly normal intestines. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
      WBPhenotype:0000709 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Arrested L1 larvae had grossly normal pharynxes. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
      WBPhenotype:0000778 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Over 90% of arrested larvae did not have any bacteria in their gut, suggesting that most nhr-67 homozygous mutantsare unable to eat. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
      WBPhenotype:0000867 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Homozygous mutants usually arrested development as embryos or L1 larvae. Homozygous ok631 adult escapers were never recovered. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
      WBPhenotype:0001412 Paper_evidence: WBPaper00039839
        Curator_confirmed: WBPerson712
        Remark: Arrested L1 larvae had grossly normal cuticular alae. Paper_evidence: WBPaper00039839
            Curator_confirmed: WBPerson712
      WBPhenotype:0001510 Paper_evidence: WBPaper00035106
        Curator_confirmed: WBPerson2021
        Remark: ASE expression of the cilia marker osm-6 is lost in lsy-9 mutants. lsy-9 affects the identity of many distinct neuron types; Both AUA and ASJ failed to undergo the normal differentiation program in nhr-67 mutants. Pan-neuronal fate is executed normally Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035106
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: osm- 6::gfp (oyIs59), See Table S1 for non-ASE markers Paper_evidence: WBPaper00035106
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001660 Paper_evidence: WBPaper00035106
        Curator_confirmed: WBPerson2021
        Remark: lsy-9 mutants display a complex phenotype in the development of left/right asymmetric ASE neurons. Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00035106
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00035106
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: gcy-7 (otIs3), lim-6 (otIs114), gcy-5 (ntIs1) Paper_evidence: WBPaper00035106
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00039839
    WBPaper00035106
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele