WormBase Tree Display for Variation: WBVar00089537

WBVar00089537 Name: Public_name: n490
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026888
      WBStrain00026889
      WBStrain00026890
      WBStrain00026891
    Laboratory: MT
    Status: Live
  Linked_to: WBVar00089538
    WBVar00089539
    WBVar01473744
  Affects: Gene: WBGene00006832
    Interactor: WBInteraction000518971
      WBInteraction000519146
      WBInteraction000537482
      WBInteraction000537483
      WBInteraction000537484
      WBInteraction000537485
      WBInteraction000537486
  Genetics: Mapping_data: In_2_point: 778
        779
        780
      In_multi_point: 702
        703
        704
        821
        822
        824
        825
        841
        1295
        1296
      In_pos_neg_data: 1362
        1430
        1435
        1440
        1445
        1449
        1453
        1486
  Description: Phenotype: WBPhenotype:0000030 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: very poor growth; n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000154 Paper_evidence: WBPaper00000914
        Curator_confirmed: WBPerson48
        Semi_dominant: Paper_evidence: WBPaper00000914
          Curator_confirmed: WBPerson48
        Phenotype_assay: Genotype: n490/n490 Paper_evidence: WBPaper00000914
              Curator_confirmed: WBPerson48
      WBPhenotype:0000175 Paper_evidence: WBPaper00000914
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: hypercontracted, n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00000914
          Person_evidence: WBPerson261
          Curator_confirmed: WBPerson48
            WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000229 Paper_evidence: WBPaper00000914
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: small, n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00000914
          Person_evidence: WBPerson261
          Curator_confirmed: WBPerson48
            WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000324 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: short, n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000425 Paper_evidence: WBPaper00049933
        Curator_confirmed: WBPerson1754
        Remark: Decreased levels of CED-4 and cytochrome C in mitochondria, Figure 6 Paper_evidence: WBPaper00049933
            Curator_confirmed: WBPerson1754
      WBPhenotype:0000546 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
      WBPhenotype:0000553 Paper_evidence: WBPaper00000914
        Curator_confirmed: WBPerson48
        Remark: The body wall musculatures of both homozygotes and heterozygotes are structurally disorganized, as revealed by a weak and abnormal birefringency pattern Paper_evidence: WBPaper00000914
            Curator_confirmed: WBPerson48
        Semi_dominant: Paper_evidence: WBPaper00000914
          Curator_confirmed: WBPerson48
      WBPhenotype:0000583 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
      WBPhenotype:0000611 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: muscle hyperactivated, n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000634 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: sticky pumping, n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00049933
          WBPaper00002305
        Curator_confirmed: WBPerson1754
          WBPerson557
        Remark: Figure 3 Paper_evidence: WBPaper00049933
            Curator_confirmed: WBPerson1754
          Severe locomotion defect. Paper_evidence: WBPaper00002305
            Curator_confirmed: WBPerson557
      WBPhenotype:0000644 Paper_evidence: WBPaper00000914
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: extremely Paper_evidence: WBPaper00000914
            Curator_confirmed: WBPerson48
          rigid paralytic; n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00000914
          Person_evidence: WBPerson261
          Curator_confirmed: WBPerson48
            WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000926 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: abnormal muscle structure, n490/+ similar but less severe phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001328 Paper_evidence: WBPaper00000914
        Curator_confirmed: WBPerson48
        Remark: phenotype observed in heterozygotes, but not in homozygotes Paper_evidence: WBPaper00000914
            Curator_confirmed: WBPerson48
        Phenotype_assay: Genotype: n490/+ Paper_evidence: WBPaper00000914
              Curator_confirmed: WBPerson48
      WBPhenotype:0001577 Paper_evidence: WBPaper00049933
        Curator_confirmed: WBPerson1754
        Remark: Figure 4D Paper_evidence: WBPaper00049933
            Curator_confirmed: WBPerson1754
      WBPhenotype:0001645 Paper_evidence: WBPaper00040284
          WBPaper00049933
        Curator_confirmed: WBPerson2987
          WBPerson1754
        Remark: Table 1 Paper_evidence: WBPaper00040284
            Curator_confirmed: WBPerson2987
          Increased muscle protein degradation, Figure 1 Paper_evidence: WBPaper00049933
            Curator_confirmed: WBPerson1754
      WBPhenotype:0001893 Paper_evidence: WBPaper00049933
        Curator_confirmed: WBPerson1754
        Remark: Figure 5 Paper_evidence: WBPaper00049933
            Curator_confirmed: WBPerson1754
      WBPhenotype:0002019 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
      WBPhenotype:0002142 Paper_evidence: WBPaper00049933
        Curator_confirmed: WBPerson1754
        Remark: Figure 5E Paper_evidence: WBPaper00049933
            Curator_confirmed: WBPerson1754
    Phenotype_not_observed: WBPhenotype:0000640 Paper_evidence: WBPaper00000914
        Curator_confirmed: WBPerson48
  Reference: WBPaper00040284
    WBPaper00000914
    WBPaper00016463
    WBPaper00014054
    WBPaper00016245
    WBPaper00015162
    WBPaper00002831
    WBPaper00049933
    WBPaper00002305
  Method: Allele