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WormBase Tree Display for Gene: WBGene00006832

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Name Class

WBGene00006832SMapS_parentSequenceC41C4
IdentityVersion2
NameCGC_nameunc-105Person_evidenceWBPerson261
Sequence_nameC41C4.5
Molecular_name (19)
Other_nameCELE_C41C4.5Accession_evidenceNDBBX284602
Public_nameunc-105
DB_infoDatabaseWormQTLgeneWBGene00006832
WormFluxgeneWBGene00006832
NDBlocus_tagCELE_C41C4.5
PanthergeneCAEEL|WormBase=WBGene00006832|UniProtKB=Q09274
familyPTHR11690
NCBIgene174306
RefSeqproteinNM_001381518.2
NM_001129123.3
NM_001377828.2
NM_001267210.3
NM_063301.6
NM_001381517.1
SwissProtUniProtAccQ09274
TrEMBLUniProtAccH2FLF8
H2FLF9
H2FLG0
E5QCG1
UniProt_GCRPUniProtAccQ09274
OMIMgene600760
600761
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
209 Jan 2012 14:54:53WBPerson1983EventAcquires_mergeWBGene00077665
Acquires_mergeWBGene00077665
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Allele (115)
Legacy_informationClass 3 (neomorphic) alleles n490sd : small hypercontracted rigid paralytic; very poor growth; abnormal muscle structure; n490/+ similar less severe phenotype. ES3. NA (dominant) 3 (n506 (ME0) n1274). Class 1 (loss-of-function) alleles; intragenic revertants of Class 3 alleles are probably null alleles e.g. n490n804 : wildtype phenotype no behavioral or muscular abnormality. NA (Class 1) > 10. Class 3 alleles also suppressed by mutations in unc-15 unc-22 unc-45 unc- 54 etc.
See also n490, n506, n785, n786, n787, n788, n795, n796, n797, n798, n799, n801, n802, n803, n804, n805, n806, n807, n808, n809, n810, n811, n812, n813, n814, n815, n816, n817, n818, n819, n820
[Reiner D]] Mac-h (Hyper-ACtivate Muscle)
[C.elegansII] n490sd : small, hypercontracted, rigid paralytic; very poor growth; abnormal muscle structure. Muscle hyperactivated, sticky pumping, short.n490/+ similar but less severe phenotype. Probable neomorphic gf allele. Suppressed by mutations in unc-15, unc-22, unc-45, unc-54etc. See also sup-20.ES3. OA2 (gf): n506 (less severe; ME0), n1274. Also intragenic revertants: n490n804 (WT, no behavioral or muscular abnormality; probable null phenotype), n490n820 etc. OA>10 (ird). Cloned: encodes degenerin family member,related to amiloride-sensitive Na channels. [Park and Horvitz 1986b; MT; RW]
StrainWBStrain00026795
WBStrain00026888
WBStrain00026889
WBStrain00026890
WBStrain00026891
WBStrain00027003
WBStrain00032015
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (45)
Paralog (30)
Structured_descriptionConcise_descriptionunc-105 encodes a muscle degenerin, a mechanosensory membrane channel that is a member of the degenerin ion channel superfamily and similar to subunits of the mammalian amiloride-sensitive epithelial sodium channel (ENaC, OMIM:600761); UNC-105 is required for normal growth and for normal contraction and organization of muscle, where it is expressed; UNC-105 interacts with LET-2, an alpha2 chain of type IV collagen that is also expressed by muscle and localized to the basement membrane between muscle and hypodermis.Paper_evidenceWBPaper00000715
WBPaper00002489
WBPaper00002490
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables monoatomic ion channel activity. Involved in calcium ion transport; magnesium ion transport; and muscle organ development. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in bronchiectasis (multiple) and renal tubular transport disease (multiple). Is an ortholog of human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0080526Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10600)
DOID:0050477Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10600,HGNC:10602)
DOID:4479Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10600,HGNC:10602)
DOID:0080528Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10602)
Molecular_infoCorresponding_CDSC41C4.5a
C41C4.5b
C41C4.5c
C41C4.5d
C41C4.5e
C41C4.5h
Corresponding_CDS_historyC41C4.5e:wp274
C41C4.5f:wp274
C41C4.5g:wp274
Corresponding_transcriptC41C4.5a.1
C41C4.5b.1
C41C4.5c.1
C41C4.5c.2
C41C4.5d.1
C41C4.5e.1
C41C4.5h.1
Other_sequenceOden_isotig26078
MH07095
Oden_isotig19678
JI175583.1
JI170191.1
Name_isotig03641
Dviv_isotig27200
GO239869.1
Associated_featureWBsf644440
WBsf654898
WBsf657933
WBsf988656
WBsf988657
WBsf1012649
WBsf221685
WBsf221686
WBsf221687
Experimental_infoRNAi_resultWBRNAi00029717Inferred_automaticallyRNAi_primary
WBRNAi00011833Inferred_automaticallyRNAi_primary
WBRNAi00042279Inferred_automaticallyRNAi_primary
WBRNAi00090191Inferred_automaticallyRNAi_primary
WBRNAi00109150Inferred_automaticallyRNAi_primary
WBRNAi00089804Inferred_automaticallyRNAi_primary
WBRNAi00042278Inferred_automaticallyRNAi_primary
WBRNAi00090032Inferred_automaticallyRNAi_primary
WBRNAi00090350Inferred_automaticallyRNAi_primary
Expr_patternExpr1021485
Expr1032895
Expr1146269
Expr2017835
Expr2035971
Drives_constructWBCnstr00034129
Construct_productWBCnstr00034129
Microarray_results (37)
Expression_cluster (123)
Interaction (54)
WBProcessWBbiopr:00000002
Map_infoMapIIPosition0.689401Error0.004244
Well_ordered
PositivePositive_cloneC41C4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point778
779
780
Multi_point (11)
Pos_neg_data1362
1430
1435
1440
1445
1449
1453
1486
Reference (67)
MethodGene