WormBase Tree Display for Picture: WBPicture0000013061

WBPicture0000013061 Description: (c) Simplified overview of phosphatidyl choline (PC) metabolism in C. elegans. P-choline, phosphorylcholine; CDP-choline, cytidyldiphosphate choline; PC, phosphatidylcholine; PS, phosphatidylserine; PS DC, phosphatidylserine decarboxylase; PE, phosphatidylethanolamine; Ptd-MeEtn, phosphatidylmonomethylethylamine. Intermediates whose levels are altered in hpl-2 mutant worms compared to wild type are shown in red. (e) Metabolism of sphingomyelin and ceramide. De novo sphingomyelin synthesis is mediated by sphingomyelin synthase (SMS), which transfers the phosphorylcholine moiety from phosphatidylcholine (PC) onto ceramide, forming sphingomyelin and diacylglycerol (DAG). In C. elegans there are three SMS genes, sms-1, -2, and -3. Ceramide can be generated either by the action of sphingomyelinase (SMase) or by de novo synthesis through the enzyme ceramide synthase (CerS, lagr-1, hyl-1 and hyl-2 in C. elegans). (f) hpl-2 regulates sms-3 mRNA levels. hpl-2/N2 ratios for sphingomyelin synthase sms genes at different developmental stages. Experiments were performed on three independent synchronized L3 cultures and on two adult and embryonic cultures. Reference genes are pmp-3 and cdc-42. Normalization was performed using the mean of both reference genes. Data are the mean of independent biological replicas.
  Name: F5.large_A.jpg
  Crop: Cropped_from: WBPicture0000013060
  Depict: WBProcess: WBbiopr:00000121
    Gene: WBGene00002043
      WBGene00004894
      WBGene00002044
      WBGene00004893
      WBGene00004892
  Acknowledgment: Template: From: <Journal_URL> <Article_URL>. Copyright <Publication_year> <Publisher_URL>.
    Publication_year: 2011
    Article_URL: DOI id 10.1186/gb-2011-12-12-r123
    Journal_URL: GenomeBiology
    Publisher_URL: BiomedCentralLTD
  Reference: WBPaper00040560