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WBPicture0000009749 | Description | (D) High magnification of ventral cord neuronal nuclei reveals that the rescuing UNC-75::GFP protein localizes to subnuclear puncta (green channel, top). UNC-75::GFP puncta do not colocalize with DAPI-stained DNA (lower two panels). (E) Deletion of the predicted nuclear localization signal (Figure 2) leads to loss of UNC-75::GFP subnuclear localization and a diffuse redistribution throughout the nucleo- and cytoplasm, including axons. (F) Subnuclear UNC-75::GFP puncta are dynamic. Images of immobilized animals taken at 10-s intervals in the same focal plane show that UNC-75 speckles are continuously moving/remodeling with the nucleus. See the Supplemental Data for the corresponding movie.(G) Human CELF4/BrunoL4::GFP localizes to subnuclear speckles in transgenic worms. | |
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Name | F3_B.jpg | ||
Crop | Cropped_from | WBPicture0000009747 | |
Depict (2) | |||
Acknowledgment (5) | |||
Reference | WBPaper00006029 |