WormBase Tree Display for Interaction: WBInteraction000535542

WBInteraction000535542 Interaction_type: Genetic: Opposing_epistasis
    GI_module_one: Trans_phenotypic
    GI_module_two: Masking
  Interactor: Interactor_overlapping_gene: WBGene00000238 Interactor_type: Effector
      WBGene00004202 Interactor_type: Affected
    Variation_interactor: WBVar00145412 Interactor_type: Effector
      WBVar00089203 Interactor_type: Affected
  Interaction_summary: "Epistasis analysis was performed with pry-1(mu38) and the mutations bar-1(ga80) and mig-14(ga62), which cause too few VPCs to adopt induced fates. The ga80 mutation introduces an early stop codon in BAR-1, and is predicted to cause a null mutant phenotype (Eisenmann et al. 1998). mig-14(ga62) is a viable, reduction-of-function mutation, which causes defects in multiple Wnt-mediated processes in embryogenesis and post-embryonic life (Eisenmann and Kim 2000). The Overinduced phenotype of pry-1(mu38) is still manifest in a double mutant with mig-14(ga62), but is strongly reduced in a double mutant with bar-1(ga80) (Table 1)." With regard to vulval cell induction, pry-1(mu38) is epistatic to mig-14(ga62) and bar-1(ga80) is epistatic to pry-1(mu38).
  Throughput: Low_throughput
  Interaction_phenotype: WBPhenotype:0001272
  Paper: WBPaper00005277
  Remark: Table 1