WormBase Tree Display for Interaction: WBInteraction000534936
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| WBInteraction000534936 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003168 | Interactor_type | Trans_regulated | |
| Expr_pattern | Marker10 | ||||
| Construct | WBCnstr00022645 | ||||
| WBGene00010775 | Interactor_type | Trans_regulator | |||
| WBGene00000802 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00093427 | Interactor_type | Trans_regulator | ||
| WBVar00092219 | Interactor_type | Trans_regulator | |||
| Interaction_summary | poml-1 mutations reduced MEC-4 protein levels in vivo as seen with fusion proteins and an anti-MEC-4 antibody. POML-1 affected the expression and distribution of MEC-4 protein, rather than the amount of mec-4 mRNA as detected by single molecule fluorescence in situ hybridization. | ||||
| The crt-1 null mutation reduced the amount of MEC-4 and its appearance as puncta in touch receptor neurons cell bodies and neurites. | |||||
| Detection_method | Construct | ||||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005237 | ||
| Paper | WBPaper00049330 | ||||
| Antibody_remark | Mouse anti-MEC-4 antibody (ab22184, Abcam, Cambridge, MA) |
