WormBase Tree Display for Interaction: WBInteraction000525095
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| WBInteraction000525095 | Interaction_type | Physical | ProteinProtein | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003378 | Interactor_type | Bait | |
| WBGene00003510 | Interactor_type | Target | |||
| Interaction_summary | Mlx ortholog, named MXL-2 for Max-like 2, and a protein that has sequence features of both Myc and Mondo proteins, named MML-1 for Myc and Mondo-like 1. MML-1/MXL-2 complexes have a primary function in regulating migration of the ray 1 precursor cells in the male tail... MML-1/MXL-2 complexes control expression of ECM components in the non-migratory epidermis, which we propose contributes to the substratum required for migration of the neighboring ray 1 precursor cells... Pro-migratory Wnt/-catenin and semaphorin signaling pathways interact genetically with MML-1/MXL-2 to determine ray 1 position... MML-1/MXL-2 complexes and semaphorin signaling act in parallel pathways in adjacent cells and synergize to determine ray 1 position... Wnt/BAR-1 and semaphorin/plexin signaling cascades act in distinct, parallel pathways to modulate ray 1 precursor cell migration. | ||||
| Detection_method | Yeast_two_hybrid | ||||
| Throughput | Low_throughput | ||||
| WBProcess | WBbiopr:00000023 | ||||
| WBbiopr:00000073 | |||||
| Paper | WBPaper00031002 | ||||
| Antibody_remark | MML-1 interacts with MXL-2 but NOT with MXL-1.... MML-1/Mondo and MDL-1/Mad did not dimerize with one another nor do they homodimerize | ||||
| Remark | Model: MML-1/MXL-2 regulation of cell adhesion and migration is consistent with a Myc-like function and broadens the role of Mondo-like proteins to include these processes. The implication of a Myc and Mondo-like factor, Wnt/-catenin, and sema- phorin/plexin signaling in cell migration leads to a model that incorporates extracellular and intracellular components (Fig. 8). MML-1/MXL-2 complexes function in the non-migratory epidermis to activate expression of lectins and collagens. Meanwhile, the combined activity of a PLX-1 pathway and BAR-1/POP-1 complexes is required in ray 1 precursors, converging on UNC-73, CED-10, and MIG-2 to promote their migratory potential. Finally, we propose that activation of all three pathways results in modulation of integrin-mediated adhesion leading to ray 1 precursor cell migration. |
